A short framework-III (mini-M-2) conotoxin from the venom of a vermivorous species, Conus archon, inhibits human neuronal nicotinic acetylcholine receptors.
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Summary
This peptide seems to be homologous to the reg3b conotoxin (from Conus regius) with an identity of 93.3%, differing only in the third residue in the sequence, serine for threonine, both uncharged polar residues.
- Type
- article
- Published
- 2022-03-01
- Cited by
- 2
- References
- 41
- OpenAlex
- https://openalex.org/W4220898178
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:247502052
Keywords
Conotoxin, Conus, Venom, Acetylcholine receptor, Nicotinic agonist
References
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- Discovery, synthesis and development of structure-activity relationships of Conotoxins
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- Conotoxin Gene Superfamilies
- Comparative protein modelling by satisfaction of spatial restraints.
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- A noncompetitive peptide inhibitor of the nicotinic acetylcholine receptor from Conus purpurascens venom.
- CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
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