Enzyme Characterization of Pro-virulent SntA, a Cell Wall-Anchored Protein of Streptococcus suis, With Phosphodiesterase Activity on cyclic-di-AMP at a Level Suited to Limit the Innate Immune System
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Summary
The efficiency of the SntA activity on c-di-AMP is comparable with the activity of CdnP that dampens type-I IFN response, suggesting that this virulence mechanism is also functional in S. suis.
- Type
- article
- Published
- 2022-03-22
- Cited by
- 14
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W4220723699
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:247768223
Keywords
Enzyme kinetics, Biochemistry, Nucleotide, Phosphodiester bond, Enzyme
References
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Cited by
- The role of bacterial cyclic di-adenosine monophosphate in the host immune response
- Genomic Distribution of Pro-Virulent cpdB-like Genes in Eubacteria and Comparison of the Enzyme Specificity of CpdB-like Proteins from Salmonella enterica, Escherichia coli and Streptococcus suis
- Novel virulence factor Cba induces antibody-dependent enhancement (ADE) of Streptococcus suis Serotype 9 infection in a mouse model
- Genomic Distribution of ushA-like Genes in Bacteria: Comparison to cpdB-like Genes
- Bacterial second messenger cyclic di‐AMP in streptococci
- Insights into the Metabolism, Signaling, and Physiological Effects of 2’,3’-Cyclic Nucleotide Monophosphates in Bacteria
- Bacterial cell volume regulation and the importance of cyclic di-AMP
- A phosphodiesterase CpdB in Yersinia pseudotuberculosis degrades CDNs to inhibit innate immune response.
- Streptococcus suis 5’-nucleotidases contribute to adenosine-mediated immune evasion and virulence in a mouse model
- Reconstruction and application of a genome-scale metabolic model for Streptococcus suis
- Cyclic-di-adenosine monophosphate regulates virulence and persistence of Streptococcus mitis CCUG 31611 in a neutropenic BALB/c mouse model
- Characterization of a novel cell wall-associated nucleotidase of Enterococcus faecalis that degrades extracellular c-di-AMP
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