The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites
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Summary
The complete gene repertoire of cruzipain in three parasite strains, their genomic organization, and expression pattern throughout the parasite life cycle are described and two families are proposed, whose genes are distributed in two or three separate clusters in the parasite genome.
- Type
- article
- Published
- 2021-07-28
- Cited by
- 30
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W3200787476
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:237515094
Keywords
Trypanosoma cruzi, Biology, Gene, Proteases, Gene family
References
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- Some kinetic properties of a cysteine proteinase (cruzipain) from Trypanosoma cruzi.
- Comparative protein modelling by satisfaction of spatial restraints.
- The crystal structure of cruzain: a therapeutic target for Chagas' disease.
- Heparan Sulfate Modulates Kinin Release by Trypanosoma cruzi through the Activity of Cruzipain*
Cited by
- Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors.
- Computational approaches towards the discovery and optimisation of cruzain inhibitors
- Vaccine Design against Chagas Disease Focused on the Use of Nucleic Acids
- Potential of sulfur-selenium isosteric replacement as a strategy for the development of new anti-chagasic drugs.
- Artificial Intelligence Technologies for Forecasting Air Pollution and Human Health: A Narrative Review
- Computational discovery of sulfonamide derivatives as potential inhibitors of the cruzain enzyme from T. cruzi by molecular docking, molecular dynamics and MM/GBSA approaches
- Rational and mechanistic approaches for improving biocatalyst performance
- From rational design to serendipity: Discovery of novel thiosemicarbazones as potent trypanocidal compounds
- Identification of inhibitors as drug candidates against Chagas disease.
- Screening the Pathogen Box to Discover and Characterize New Cruzain and TbrCatL Inhibitors
- Structure-based discovery of novel cruzain inhibitors with distinct trypanocidal activity profiles.
- 1,3-Thiazole derivatives as privileged structures for anti-Trypanosoma cruzi activity: Rational design, synthesis, in silico and in vitro studies.
- Structure‐based design, optimization of lead, synthesis, and biological evaluation of compounds active against Trypanosoma cruzi
- Dual localization of receptor-type adenylate cyclases and cAMP response protein 3 unveils the presence of two putative signaling microdomains in Trypanosoma cruzi
- Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets
- Finding for New Drugs in Nature for Neglected Tropical Diseases: In Silico Study of Homolycorine Alkaloids Against Chagas Disease
- Comparative membrane proteomic analysis of Tritrichomonas foetus isolates
- Structure-Aided Computational Design of Triazole-Based Targeted Covalent Inhibitors of Cruzipain
- Discovery of a Potent Triazole-Based Reversible Targeted Covalent Inhibitor of Cruzipain.
- MOLECULAR HOST-PARASITE INTERACTION AT THE SITE OF VECTOR BITE.
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