Lipid nanoparticles for mRNA delivery
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Summary
Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA and lipid nanoparticle–mRNA vaccines are now in clinical use against coronavirus disease 2019 (COVID-19), which marks a milestone for mRNA therapeutics.
- Type
- review
- Published
- 2021-08-10
- Cited by
- 3,399
- References
- 260
- Access
- Open access
- OpenAlex
- https://openalex.org/W3188940990
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:236972641
Keywords
Messenger RNA, Translation (biology), Nanoparticle, Nucleic acid, RNA
References
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- Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
- Who discovered messenger RNA?
- Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals
- Oxygen Radical-Mediated Pulmonary Toxicity Induced by Some Cationic Liposomes
- In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles
- Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
- mRNA-based therapeutics — developing a new class of drugs
- Complement activation-related pseudoallergy: a stress reaction in blood triggered by nanomedicines and biologicals.
- Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells.
- Innate immune response and programmed cell death following carrier-mediated delivery of unmodified mRNA to respiratory cells.
- The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage.
- Evidence for translation of rabbit globin mRNA after liposomemediated insertion into a human cell line
- Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA.
- RNA Melanoma Vaccine: Induction of Antitumor Immunity by Human Glycoprotein 100 mRNA Immunization
- A cationic nanoemulsion for the delivery of next-generation RNA vaccines.
- Degradable Lipid Nanoparticles with Predictable In Vivo siRNA Delivery Activity
Cited by
- Massively parallel pooled screening reveals genomic determinants of nanoparticle-cell interactions
- Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides
- Challenges and Scientific Prospects of the Newest Generation of mRNA-Based Vaccines against SARS-CoV-2
- Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment
- A Review on Current COVID-19 Vaccines and Evaluation of Particulate Vaccine Delivery Systems
- Lipids: An Atomic Toolkit for the Endless Frontier.
- Heterogeneous Longitudinal Antibody Responses to Covid-19 mRNA Vaccination
- Bioinspired Silicification of mRNA-Loaded Polyion Complexes for Macrophage-Targeted mRNA Delivery.
- Ultrasonic particles: An approach for targeted gene delivery
- A Perspective on Nanotechnology and COVID-19 Vaccine Research and Production in South Africa
- Principles for designing an optimal mRNA lipid nanoparticle vaccine
- Role of Ionizable Lipids in SARS-CoV-2 Vaccines As Revealed by Molecular Dynamics Simulations: From Membrane Structure to Interaction with mRNA Fragments
- Near Infrared Fluorescent Nanostructure Design for Organic/Inorganic Hybrid System
- Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
- Overcoming transport barriers to immunotherapy
- Zwitterionic polymers in drug delivery: A review
- The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective
- Microfluidic nanomaterials: From synthesis to biomedical applications.
- Delivery of CRISPR-Cas9 system for screening and editing RNA binding proteins in cancer
- Brief on Recent Application of Liposomal Vaccines for Lower Respiratory Tract Viral Infections: From Influenza to COVID-19 Vaccines
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