Genome mining for drug discovery: progress at the front end
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Summary
As microbial genome mining has matured in recent years, unvalidated conjectures about what microbes to pursue, how to identify legitimate secondary metabolite BGCs, and how to sequence DNA to satisfactory levels of completion have been identified and the solutions to correct the misconceptions are beginning to be implemented.
- Type
- review
- Published
- 2021-07-19
- Cited by
- 50
- References
- 99
- Access
- Open access
- OpenAlex
- https://openalex.org/W3186946335
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:236090450
Keywords
Drug discovery, Genome, Computational biology, Biology, Data science
References
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- Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
- Antibiotic resistance–mediated isolation of scaffold-specific natural product producers
- MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus
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- Structural modifications of glycopeptide antibiotics
- Importance of microbial natural products and the need to revitalize their discovery
- Genome mining of the Streptomycesavermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters
Cited by
- Microbiome First Medicine in Health and Safety
- The Methods of Digging for “Gold” within the Salt: Characterization of Halophilic Prokaryotes and Identification of Their Valuable Biological Products Using Sequencing and Genome Mining Tools
- Genome mining methods to discover bioactive natural products
- Discovery of unusual dimeric piperazyl cyclopeptides encoded by a Lentzea flaviverrucosa DSM 44664 biosynthetic supercluster
- Artificial intelligence in microbial natural product drug discovery: current and emerging role
- N-Succinyltransferase Encoded by a Cryptic Siderophore Biosynthesis Gene Cluster in Streptomyces Modifies Structurally Distinct Antibiotics
- Concepts and conjectures concerning predatory performance of myxobacteria
- Expanding the genomic encyclopedia of Actinobacteria with 824 isolate reference genomes
- Sequence Controlled Secondary Structure Determines Site-selectivity of Lanthipeptides
- Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters
- Genetic manipulation and tools in myxobacteria for the exploitation of secondary metabolism
- A remarkable transformation catalyzed by a domain-of-unknown-function 692 during the biosynthesis of a new RiPP natural product
- Beyond Ergosterol: Strategies for Combatting Antifungal Resistance in Aspergillus fumigatus and Candida auris
- Macrocyclization and Backbone Rearrangement During RiPP Biosynthesis by a SAM-Dependent Domain-of-Unknown-Function 692
- Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery
- Isolation of two new stereochemical variants of streptophenazine by cocultivation of Streptomyces NIIST-D31, Streptomyces NIIST-D47, and Streptomyces NIIST-D63 strains in 3C2 combinations
- BGCFlow: systematic pangenome workflow for the analysis of biosynthetic gene clusters across large genomic datasets
- Micrococcus spp. as a promising source for drug discovery: A review
- Chromosomal organization of biosynthetic gene clusters, including those of nine novel species, suggests plasticity of myxobacterial specialized metabolism
- Streptomyces lividans 66 produces a protease inhibitor via a tRNA-utilizing enzyme interacting with a C-minus NRPS
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