Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review
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Summary
Good evidence to recommend polyethylene glycol or senna as first-line laxatives and moderate evidence supporting fiber supplements, fruits, stimulant laxatives, and magnesium-based products are found.
- Type
- review
- Published
- 2021-03-17
- Cited by
- 76
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W3137846503
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:232367503
Keywords
Medicine, Tegaserod, Laxative, Psyllium, Adverse effect
References
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- Randomized, double-blind, placebo-controlled trial of Ficus carica paste for the management of functional constipation.
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- A Comparison of Polyethylene Glycol Laxative and Placebo for Relief of Constipation From Constipating Medications
- The pathophysiology of chronic constipation.
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- Macrogol for the treatment of constipation in Parkinson's disease. A randomized placebo‐controlled study
- Efficacy and safety of a magnesium sulfate-rich natural mineral water for patients with functional constipation.
- Healthcare costs among patients with chronic constipation: a retrospective claims analysis in a commercially insured population
- Prospective randomized crossover trial comparing fibre with lactulose in the treatment of idiopathic chronic constipation
- Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation
- Randomised clinical trial: macrogol/PEG 3350+electrolytes versus prucalopride in the treatment of chronic constipation ‐ a comparison in a controlled environment
- Psychological profiles and quality of life differ between patients with dyssynergia and those with slow transit constipation.
- A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation
- Clinical trial: single‐ and multiple‐dose pharmacokinetics of polyethylene glycol (PEG‐3350) in healthy young and elderly subjects
- Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects
- Comparison of Polyethylene Glycol with and without Electrolytes in the Treatment of Constipation in Elderly Institutionalized Patients
- Effects of kivia powder on Gut health in patients with occasional constipation: a randomized, double-blind, placebo-controlled study
- Effects of chicory inulin in constipated elderly people: a double-blind controlled trial
- Effect of an oral bulking agent and a rectal laxative administered alone or in combination for the treatment of constipation.
Cited by
- Chronic Idiopathic Constipation in Adults: A Review on Current Guidelines and Emerging Treatment Options
- Prune intake ameliorates chronic constipation symptoms and causes little discomfort from diarrhea and loose stools: A randomized placebo-controlled trial
- Mechanisms of Action of Current Pharmacologic Options for the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation
- Real-World Treatment Strategies to Improve Outcomes in Patients With Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation
- Evidence-based treatment recommendations for OTC management of chronic constipation
- Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial
- The Relationship between Gastrointestinal Health, Micronutrient Concentrations, and Autoimmunity: A Focus on the Thyroid
- Polyethylene Glycol 3350 in the Treatment of Chronic Idiopathic Constipation: Post hoc Analysis Using FDA Endpoints
- Constipation and Fecal Incontinence in the Elderly
- A nurse-led educational intervention for relieving idiopathic constipation: a retrospective study.
- Prevention of Postoperative Constipation in Urogynecology Patients: A Systematic Review
- Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants
- Exploring the Dose–Effect Relationship of Bifidobacterium longum in Relieving Loperamide Hydrochloride-Induced Constipation in Rats through Colon-Released Capsules
- The practical management of chronic constipation as detected by a survey conducted on Italian gastroenterologists
- American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation
- American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation
- The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta‐analysis of randomized controlled trials
- The Burden and Treatment of Chronic Constipation Among US Nursing Home Residents
- Green and gold kiwifruit powders consumed for 28 days by healthy individuals with occasional constipation are safe and well-tolerated: A randomized controlled trial.
- Herbal Remedies for Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review of Randomized Controlled Trials
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