Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoes
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Summary
It is demonstrated that some DVGs present broad-spectrum activity, inhibiting several CHIKV strains and other alphaviruses, and that pre-treating Aedes aegypti with DVGs prevented viral dissemination in vivo.
- Type
- article
- Published
- 2021-02-01
- Cited by
- 43
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W3127272920
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:231862628
Keywords
Chikungunya, Virology, Alphavirus, Biology, Virus
References
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Cited by
- Single-cell transcriptomic analysis of antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts
- De-Coding the Contributions of the Viral RNAs to Alphaviral Pathogenesis
- A defective viral genome strategy elicits broad protective immunity against respiratory viruses
- Chikungunya virus produced by a persistently infected mosquito cell line comprises a shorter genome and is non-infectious to mammalian cells.
- Prospects on Repurposing a Live Attenuated Vaccine for the Control of Unrelated Infections
- Characterisation of the RNA Virome of Nine Ochlerotatus Species in Finland
- Treatment of Sindbis Virus-Infected Neurons with Antibody to E2 Alters Synthesis of Complete and nsP1-Expressing Defective Viral RNAs
- A Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus
- Evolution of naturally arising SARS-CoV-2 defective interfering particles
- Generation of “OP7 chimera” defective interfering particle preparations free of infectious influenza A virus that shows antiviral efficacy in mice
- Broad-Spectrum Antiviral Activity of Influenza A Defective Interfering Particles against Respiratory Syncytial, Yellow Fever, and Zika Virus Replication In Vitro
- Unveiling the biology of defective viral genomes in vitro and in vivo: implications for gene expression and pathogenesis of coronavirus
- Biological characterization of coronavirus noncanonical transcripts in vitro and in vivo
- Open questions in the social lives of viruses
- Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice
- Production of antiviral “OP7 chimera” defective interfering particles free of infectious virus
- Mathematical model calibrated to in vitro data predicts mechanisms of antiviral action of the influenza defective interfering particle “OP7”
- Defective viral genomes: advances in understanding their generation, function, and impact on infection outcomes
- Accumulation Dynamics of Defective Genomes during Experimental Evolution of Two Betacoronaviruses
- Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy
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