Transaminase-mediated synthesis of enantiopure drug-like 1-(3′,4′-disubstituted phenyl)propan-2-amines
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Summary
The application of immobilised whole-cell biocatalysts with (R)-transaminase activity for the synthesis of novel disubstituted 1-phenylpropan-2-amine derivatives starting from prochiral ketones is reported.
- Type
- article
- Published
- 2020-11-09
- Cited by
- 3
- References
- 72
- Access
- Open access
- OpenAlex
- https://openalex.org/W3100789542
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:229234022
Keywords
Enantiopure drug, Transaminase, Chemistry, Drug, Medicinal chemistry
References
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- Features and technical applications of ω-transaminases
- Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
- RESOLUTION OF CHIRAL ALIPHATIC AND ARYLALKYL AMINES USING IMMOBILIZED CANDIDA ANTARCTICA LIPASE AND ISOLATION OF THEIR R- AND S-ENANTIOMERS
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- Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction
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- Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow mode
- Preparation of (R)-Amines from Racemic Amines with an (S)-Amine Transaminase from Bacillus megaterium
- A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (+/-)-crispine A.
Cited by
- Enantioselective Chromatographic Separation and Lipase Catalyzed Asymmetric Resolution of Biologically Important Chiral Amines
- Non-Canonical Amino Acid-Based Engineering of (R)-Amine Transaminase
- Transaminase-mediated chiral selective synthesis of (1R)-(3-methylphenyl)ethan-1-amine from 1-(3-methylphenyl)ethan-1-one: process minutiae, optimization, characterization and ‘What If studies’
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