Identifying RNA Helicase Inhibitors Using Duplex Unwinding Assays

Keywords

Helicase, RNA Helicase A, Computational biology, RNA, Biology

References

• Unzippers, Resolvers and Sensors: A Structural and Functional Biochemistry Tale of RNA HelicasesAna Lúcia Leitão, Marina C. Costa, Francisco J. Enguita — 2015
• Spectrophotometric assay for enzyme-mediated unwinding of double-stranded DNA.P Houston, Thomas Kodadek — 1994
• Coupling of DNA unwinding to nucleotide hydrolysis in a ring‐shaped helicaseIlker Donmez, Smita S. Patel — 2008
• Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex.Alan J. Tackett — 2001
• Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assaysSourav Mukherjee, Alicia M. Hanson, William R. Shadrick — 2012
• Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral HelicaseNoreena L. Sweeney, Alicia M. Hanson, Sourav Mukherjee — 2015
• Unravelling the Mechanisms of RNA Helicase Regulation.Katherine E. Sloan, Markus T. Bohnsack — 2018
• New Insights Into DNA Helicases as Druggable Targets for Cancer TherapyArindam Datta, Robert M. Brosh — 2018
• N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3John C. Marecki, Suja Aarattuthodiyil, Alicia K. Byrd — 2018
• Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21Dae-Seok Kim, Cristel V. Camacho, Anusha Nagari — 2019
• Bacterial replisomes.Zhi‐Qiang Xu, Nicholas E. Dixon — 2018

Cited by

• RNA helicases required for viral propagation in humansJohn C. Marecki, Binyam Belachew, Jun Gao — 2021
• RECQ5 mediates pre-rRNA processing in nucleolusYidi Ma, Xiaochun Yu — 2025
• Structure, Function and Inhibition of Helicases Involved in Virus InfectionGisoo Sarvari, David D. Boehr — 2026
• Repurposing drug screen for the identification of helicase inhibitors from viruses of pandemic concernNicole L. Inniss, Margarita Rzhetskaya, Ryan P Kich — 2026

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