A hepatocellular carcinoma–bone metastasis-on-a-chip model for studying thymoquinone-loaded anticancer nanoparticles
Explore this paper's citation graph
Summary
A HCC–bone metastasis-on-a-chip platform was demonstrated to model certain key aspects of the cancer metastasis process, hence corroborating the potential of enabling investigations on metastasi-associated biology as well as improved anti-metastatic drug screening.
- Type
- article
- Published
- 2020-05-13
- Cited by
- 61
- References
- 30
- OpenAlex
- https://openalex.org/W3024066835
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:219413137
Keywords
Metastasis, Hepatocellular carcinoma, Bone metastasis, Cancer research, Thymoquinone
References
- A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells
- Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique.
- Chitosan microspheres as a potential carrier for drugs.
- Epidemiology of primary and secondary liver cancers.
- Dual drug-loaded paclitaxel–thymoquinone nanoparticles for effective breast cancer therapy
- Extrahepatic metastases of hepatocellular carcinoma.
- Delivery of phytochemical thymoquinone using molecular micelle modified poly(D, L lactide-co-glycolide) (PLGA) nanoparticles
- Release Kinetics Study of Poorly Water-Soluble Drugs from Nanoparticles: Are We Doing It Right?
- A Microfluidic 3D In Vitro Model for Specificity of Breast Cancer Metastasis to Bone
- Microfluidic platforms for the study of cancer metastasis
- Microenvironmental regulation of metastasis
- Contributions of the host microenvironment to cancer-induced bone disease
- Elastic modulus measurements of human liver and correlation with pathology.
- Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles.
- Two-step method for encapsulation of oregano essential oil in chitosan nanoparticles: preparation, characterization and in vitro release study.
- A combined microfluidic coculture and multiphoton FAD analysis assay enables insight into the influence of the bone microenvironment on prostate cancer cells
- Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting
- Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms
- Bioactive nanoengineered hydrogels for bone tissue engineering: a growth-factor-free approach.
- The role of extracellular calcium in bone metastasis
Cited by
- Engineering in vitro human tissue models through bio-design and manufacturing
- The Cancer Microenvironment: Mechanical Challenges of the Metastatic Cascade
- Tumor-on-chip modeling of organ-specific cancer and metastasis.
- Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis
- Therapeutic perspectives of the black cumin component thymoquinone: A review.
- Continuous Microfluidic Production of Citrem-Phosphatidylcholine Nano-Self-Assemblies for Thymoquinone Delivery
- On-demand manipulation of tumorigenic microenvironments by nano-modulator for synergistic tumor therapy.
- Experimental Models of Hepatocellular Carcinoma—A Preclinical Perspective
- Recent advances in the development of in vitro liver models for hepatotoxicity testing
- Anticancer activities of bioactive peptides derived from rice husk both in free and encapsulated form in chitosan
- Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
- Multi-organ-on-chip approach in cancer research
- Organ on Chip Technology to Model Cancer Growth and Metastasis
- Photoacoustic Imaging of 3D-Printed Vascular Networks
- Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Recent advances for cancer detection and treatment by microfluidic technology, review and update
- Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology
- Anti-cancer activity of naringenin loaded smart polymeric nanoparticles in breast cancer
- Construction and application of liver cancer models in vitro
- Micro-Nanocarriers Based Drug Delivery Technology for Blood-Brain Barrier Crossing and Brain Tumor Targeting Therapy.
Related papers
- Histological and biochemical evaluation of the possible protective effect of thymoquinone loaded nanostructured lipid carriers versus thymoquinone on cisplatin induced testicular toxicity in adult rats.
- Therapeutic perspectives of the black cumin component thymoquinone: A review.
- Anti-hyperglycemic and hepato-protective effects of thymoquinone (Nigella sativa oil) in diabetes
- The effect of thymoquinone on blood lipids in rats.
- Response of Skin-Derived and Metastatic Human Malignant Melanoma Cell Lines to Thymoquinone and Thymoquinone-Loaded Liposomes
- The Comparison of Anticancer Activity of Thymoquinone and Nanothymoquinone on Human Breast Adenocarcinoma
- Improving prognosis of patients with very early hepatocellular carcinoma: How far are we going?
- HCC-Mark: a simple non-invasive model based on routine parameters for predicting hepatitis C virus related hepatocellular carcinoma
- Demethylation of miR-34a upregulates expression of membrane palmitoylated proteins and promotes the apoptosis of liver cancer cells
- Isolated perfused liver: a model for studies on cancer-cell dissemination.