An update on targets for treating osteoarthritis pain: NGF and TRPV1
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Summary
An update on the current clinical and preclinical studies targeting two pathways for treating OA pain: the nerve growth factor (NGF) pathway and the transient receptor potential vanilloid-1 (TRPV1) pathway is given.
- Type
- article
- Published
- 2020-05-06
- Cited by
- 19
- References
- 80
- Access
- Open access
- OpenAlex
- https://openalex.org/W3022426772
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:218513765
Keywords
TRPV1, Osteoarthritis, Medicine, Physical medicine and rehabilitation, Neuroscience
References
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- Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes.
- Structural Associations of Symptomatic Knee Osteoarthritis
- Deficits in spontaneous burrowing behavior in the rat bilateral monosodium iodoacetate model of osteoarthritis: an objective measure of pain-related behavior and analgesic efficacy.
- Pre-treatment with capsaicin in a rat osteoarthritis model reduces the symptoms of pain and bone damage induced by monosodium iodoacetate.
- Afferent Drive Elicits Ongoing Pain in a Model of Advanced Osteoarthritis
- A‐995662 [(R)‐8‐(4‐methyl‐5‐(4‐(trifluoromethyl)phenyl)oxazol‐2‐ylamino)‐1,2,3,4‐tetrahydronaphthalen‐2‐ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model
- Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain
- A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis
- Long-term analgesic effect of a single dose of anti-NGF antibody on pain during motion without notable suppression of joint edema and lesion in a rat model of osteoarthritis.
- TRPV1-related modulation of spinal neuronal activity and behavior in a rat model of osteoarthritic pain.
- Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non‐inflammatory joint pain
- Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees.
- Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.
- Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement.
- Serious joint-related adverse events in randomized controlled trials of anti-nerve growth factor monoclonal antibodies.
- The pharmacological challenge to tame the transient receptor potential vanilloid‐1 (TRPV1) nocisensor
- Repeated dosing of ABT‐102, a potent and selective TRPV1 antagonist, enhances TRPV1‐mediated analgesic activity in rodents, but attenuates antagonist‐induced hyperthermia
- Towards a mechanism-based approach to pain management in osteoarthritis
- Presurgical assessment of temporal summation of pain predicts the development of chronic postoperative pain 12 months after total knee replacement
Cited by
- Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.
- The challenges of treating osteoarthritis pain and opportunities for novel peripherally directed therapeutic strategies.
- Sex-Related Pain Behavioral Differences following Unilateral NGF Injections in a Rat Model of Low Back Pain
- Modulatory Effect of Neurotrophic Factors on the TRPV1 Expression: Possible Mechanisms Involved in the Antiepileptic Effect of Exercise
- The periodontal ligament, temperature-sensitive ion channels TRPV1-4, and the mechanosensitive ion channels Piezo1 and 2: A Nobel connection.
- Structural and functional characterisation of Tst2, a novel TRPV1 inhibitory peptide from the Australian sea anemone Telmatactis stephensoni.
- Bioactives and their roles in bone metabolism of osteoarthritis: evidence and mechanisms on gut-bone axis
- The challenge of pharmacotherapy for musculoskeletal pain: an overview of unmet needs
- Pharmacotherapy for osteoarthritis-related pain: current and emerging therapies
- A Review of Current Approaches to Pain Management in Knee Osteoarthritis with a Focus on Italian Clinical Landscape
- Targeting the TRPV1 pain pathway in osteoarthritis of the knee
- Effect of Interdisciplinary Discharge Programme on Daily Function, Quality of Life, and Pain Intensity in Patients Undergoing Joint Replacement Surgery
- Mechanosensitive ion channels and inflammation: key links in cellular signal transduction
- From neuromodulation to bone homeostasis: therapeutic targets of nerve growth factor in skeletal diseases
- Possible Anti-Pain Vaccines: A Narrative Review of Emerging Strategies and Clinical Prospects
- Mechanical stimulation simulating osteopathic pressing manipulation inhibits nociceptive hypersensitivity and synovial inflammation in knee osteoarthritis rats by modulating trafficking dynamics of transient receptor potentials via complexin2
- Sensory nerves protect against preclinical tendinopathic changes through FGF1 signaling.
- New Adjuvant Therapies for Obesity-Related Disorders Associated with Meta-Neuroinflammation
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