Extracorporeal cytokine adsorption for treating severe refractory cytokine release syndrome (CRS)
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Summary
The case of a 79-year-old patient treated in the haematology ward of the authors' academic hospital for an aggressive diffuse large B-cell lymphoma refractory to several lines of therapy with a Tcell-engaging bispecific antibody, who developed a grade-2 CRS that rapidly deteriorated to grade 4 and needed intensive care unit (ICU) admission for appropriate management.
- Type
- article
- Published
- 2020-04-10
- Cited by
- 7
- References
- 23
- OpenAlex
- https://openalex.org/W3015280362
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:215725001
Keywords
Medicine, Cytokine, Refractory (planetary science), Cytokine release syndrome, Extracorporeal
References
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- CAR T cell immunotherapy for human cancer
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- Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
- Clinical and Biologic Correlates of Neurotoxicity Associated with CAR T Cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia (B-ALL)
- Effect of renal clearance and continuous renal replacement therapy on appropriateness of recommended meropenem dosing regimens in critically ill patients with susceptible life-threatening infections
- GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts.
- In vitro removal of anti-infective agents by a novel cytokine adsorbent system
- ASBMT Consensus Grading for Cytokine Release Syndrome and Neurological Toxicity Associated with Immune Effector Cells
- Toxicities of CD19 CAR‐T cell immunotherapy
- Management of cytokine release syndrome and neurotoxicity in chimeric antigen receptor (CAR) T cell therapy
- Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis
Cited by
- Suivi immunologique des traitements par cellules CAR-T
- The Potential Role of Extracorporeal Cytokine Removal in Hemodynamic Stabilization in Hyperinflammatory Shock
- Adjuvant hemoadsorption therapy in patients with severe COVID-19 and related organ failure requiring CRRT or ECMO therapy: A case series
- CAR-T cell: Toxicities issues: Mechanisms and clinical management.
- Hemoadsorption in Organ Preservation and Transplantation: A Narrative Review
- Cytokine release syndrome after CAR T-cell therapy for B-cell acute lymphoblastic leukemia in children and young adolescents: storms make trees take deeper roots
- Hemoadsorption as a Supportive Strategy for Severe Toxicity Associated With Chimeric Antigen Receptor T-Cell Therapy: A Case Series
- Hemoadsorption in Organ Preservation and Transplantation: A Narrative Review
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