Qishen granules exerts cardioprotective effects on rats with heart failure via regulating fatty acid and glucose metabolism
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Summary
QSG improved myocardial energy metabolism through increasing FA metabolism,hibiting uncoupling of glycolysis from glucose oxidation and restoring the mitochondrial function by increasing SUCLA2, CKMT2 and PGC-1α and decreasing UCP2 simultaneously.
- Type
- article
- Published
- 2020-03-04
- Cited by
- 30
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W3010652367
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:211836387
Keywords
Heart failure, Metabolism, Medicine, Fatty acid metabolism, Carbohydrate metabolism
References
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- PPAR signaling in the control of cardiac energy metabolism.
- Mitochondrial UCP2 in the central regulation of metabolism.
- CD36, but not GPR120, is required for efficient fatty acid utilization during endurance exercise
- The PPAR-RXR Transcriptional Complex in the Vasculature: Energy in the Balance
- Qishenyiqi Protects Ligation-Induced Left Ventricular Remodeling by Attenuating Inflammation and Fibrosis via STAT3 and NF-κB Signaling Pathway
- Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years.
- Epidemiology of heart failure and scope of the problem.
- Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle
- PPARs: fatty acid sensors controlling metabolism.
- Cardiac Energy Metabolic Alterations in Pressure Overload–Induced Left and Right Heart Failure (2013 Grover Conference Series)
- Magnetic Resonance Imaging and Invasive Evaluation of Development of Heart Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α
- Too Much or Not Enough of a Good Thing? Cardiac Glucolipotoxity versus Lipoprotection
- Comparison of segmentation methods for MRI measurement of cardiac function in rats
- Protection of erythropoietin against ischemic neurovascular unit injuries through the effects of connexin43.
- The annual global economic burden of heart failure.
- Nuclear receptor signaling and cardiac energetics.
Cited by
- Modulatory Effects of Chinese Herbal Medicines on Energy Metabolism in Ischemic Heart Diseases
- Fecal metabolomics based on mass spectrometry to investigate the mechanism of qishen granules on isoproterenol-induced chronic heart failure in rats.
- Protective effect of Yi-Qi-Huo-Xue Decoction against ischemic heart disease by regulating cardiac lipid metabolism.
- Systematic Analysis of tRNA-Derived Small RNAs Discloses New Therapeutic Targets of Caloric Restriction in Myocardial Ischemic Rats
- Mechanism of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure
- Effects of Guanxinshutong Capsules as Complementary Treatment in Patients With Chronic Heart Failure: Study Protocol for a Randomized Controlled Trial
- The Protective Effect of Shuxin Shengmai Dan on Myocardial Ischemia-Reperfusion Injury in Rats
- aFGF Targeted Mediated by Novel Nanoparticles-Microbubble Complex Combined With Ultrasound-Targeted Microbubble Destruction attenuates Doxorubicin-Induced Heart Failure via Anti-Apoptosis and Promoting Cardiac Angiogenesis
- Integration of segmented regression analysis with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues
- Traditional Chinese medicine enhances myocardial metabolism during heart failure.
- Mechanistic Insights of Qingre Jiedu Recipe Based on Network Pharmacology Approach against Heart Failure
- A Network Pharmacology Study on the Active Components and Targets of the Radix Ginseng and Radix Bupleuri Herb Pair for Treating Nonalcoholic Fatty Liver Disease
- Exercise-Generated β-Aminoisobutyric Acid (BAIBA) Reduces Cardiomyocyte Metabolic Stress and Apoptosis Caused by Mitochondrial Dysfunction Through the miR-208b/AMPK Pathway
- Effect of Qishen granules on isoproterenol‐induced chronic heart failure in rats evaluated by comprehensive metabolomics
- Qishen Granule Protects against Doxorubicin-Induced Cardiotoxicity by Coordinating MDM2-p53-Mediated Mitophagy and Mitochondrial Biogenesis
- Cardiac energy metabolism disorder mediated by energy substrate imbalance and mitochondrial damage upon tebuconazole exposure.
- Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha.
- Qishen granules regulate intestinal microecology to improve cardiac function in rats with heart failure
- Sports and Chinese herbal medicine
- Energy metabolism: A critical target of cardiovascular injury.
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