Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling
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Summary
A novel target of icariin is described that has potential applications in the treatment of osteogenic disorders and promoted osteogenic differentiation through BMAL1-BMP2 signaling in BMSCs.
- Type
- article
- Published
- 2020-01-20
- Cited by
- 38
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W2999492163
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:210991189
Keywords
Icariin, RUNX2, Bone morphogenetic protein 2, Chemistry, Cell biology
References
- Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor‐dependent osteoblastic functions in UMR 106 cells
- Turning Bone Morphogenetic Protein 2 (BMP2) On and Off in Mesenchymal Cells
- Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today? A Ten-Year Update.
- The adipocyte clock controls brown adipogenesis through the TGF‐&bgr; and BMP signaling pathways
- Roles of brain and muscle ARNT‐like 1 and Wnt antagonist Dkk1 during osteogenesis of bone marrow stromal cells
- Changes in Runx2/Cbfa1 Expression and Activity During Osteoblastic Differentiation of Human Bone Marrow Stromal Cells
- Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways.
- Inhibitory role of REV-ERBα in the expression of bone morphogenetic protein gene family in rat uterus endometrium stromal cells.
- Natural history of mesenchymal stem cells, from vessel walls to culture vessels
- Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat diet in mice.
- Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions
- Mechanism of the circadian clock in physiology.
- BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development
- BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes.
- α1-Adrenergic Receptor Signaling in Osteoblasts Regulates Clock Genes and Bone Morphogenetic Protein 4 Expression through Up-regulation of the Transcriptional Factor Nuclear Factor IL-3 (Nfil3)/E4 Promoter-binding Protein 4 (E4BP4)*
- Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway.
- Circadian regulation of the hepatic endobiotic and xenobitoic detoxification pathways: the time matters.
- The hepatic circadian clock modulates xenobiotic metabolism in mice
- CIRCADIAN REGULATION OF METABOLISM
- Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Cited by
- Prospects of circadian clock in joint cartilage development
- Integrative proteomics and metabolomics profiling of the protective effects of Phascolosoma esculent ferritin on BMSCs in Cd(II) injury.
- In vivo effect of the Chinese Tenghuang Jiangu Formula on cartilage destruction and subchondral bone sclerosis
- Effect of N-cadherin on Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells through Wnt Signaling Pathway.
- Neohesperidin promotes the proliferation and osteogenic differentiation of BMSCs via BMP2-Wnt/β-catenin pathway
- The mechanism of Danzikang Knee Granule in regulating the chondrogenic differentiation of mesenchymal stem cells based on TGF-β signaling pathway in cartilage repair in knee osteoarthritis.
- Bmal1 promotes cementoblast differentiation and cementum mineralization via Wnt/β-catenin signaling.
- The potential mechanism of Fructus Ligustri Lucidi promoting osteogenetic differentiation of bone marrow mesenchymal stem cells based on network pharmacology, molecular docking and experimental identification
- The circadian clock has roles in mesenchymal stem cell fate decision
- Immunomodulatory effects of icariin in a myocardial infarction mouse model
- Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats
- Co-regulation of circadian clock genes and microRNAs in bone metabolism
- Icariin promotes the repair of bone marrow mesenchymal stem cells in rabbit knee cartilage defects via the BMP/Smad pathway
- Deciphering clock genes as emerging targets against aging.
- Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1
- Circadian clock genes as promising therapeutic targets for bone loss.
- Long non‐coding RNA telomerase RNA elements improve glucocorticoid‐induced osteoporosis by EZH2 to regulate DKK1
- BMAL1 Promotes Valvular Interstitial Cells’ Osteogenic Differentiation through NF-κ B/AKT/MAPK Pathway
- Icariin activates far upstream element binding protein 1 to regulate hypoxia-inducible factor-1α and hypoxia-inducible factor-2α signaling and benefits chondrocytes
- Exploring the mechanism of Astragali radix for promoting osteogenic differentiation based on network pharmacology, molecular docking, and experimental validation
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