Long noncoding RNA glutathione peroxidase 3–antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract
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Summary
The lncRNA GPX3-AS, which is located in the nuclei of LECs, was downregulated in cataractous human lenses compared with control lenses, and proapoptotic proteins were expressed at high levels in the anterior lens capsules of ARC tissues.
- Type
- article
- Published
- 2019-11-14
- Cited by
- 26
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W2994754131
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:208651225
Keywords
GPX3, Biology, TUNEL assay, Molecular biology, Apoptosis
References
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- Complications in resident-performed phacoemulsification cataract surgery at New Jersey Medical School
- p53-induced Gene 3 Mediates Cell Death Induced by Glutathione Peroxidase 3*
- Oxidative DNA damage in patients with cataract
- Up-Regulation of NDRG2 in Senescent Lens Epithelial Cells Contributes to Age-Related Cataract in Human
- The Xenobiotic-Metabolizing Enzymes Arylamine N-Acetyltransferases in Human Lens Epithelial Cells: Inactivation by Cellular Oxidants and UVB-Induced Oxidative Stress
- Antioxidant and Protective Mechanisms against Hypoxia and Hypoglycaemia in Cortical Neurons in Vitro
- The oxidative stress in cataract patients.
- Tumor suppressor function of the plasma glutathione peroxidase Gpx3 in colitis-associated carcinoma
- A Comparative Study of Techniques for Differential Expression Analysis on RNA-Seq Data
- Regulation of Chromatin Structure by Long Noncoding RNAs: Focus on Natural Antisense Transcripts
- The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells
- Role of long non‐coding RNA MIAT in proliferation, apoptosis and migration of lens epithelial cells: a clinical and in vitro study
- Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression
- Prevalence of Age-Related Cataract and Cataract Surgery in a Chinese Adult Population: The Taizhou Eye Study.
Cited by
- GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment
- CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a
- MDM2 phosphorylation mediates H2O2-induced lens epithelial cells apoptosis and age-related cataract.
- Research Progress of Drug Prophylaxis for Lens Capsule Opacification after Cataract Surgery
- Polygenetic-Risk Scores Related to Crystallin Metabolism Are Associated with Age-Related Cataract Formation and Interact with Hyperglycemia, Hypertension, Western-Style Diet, and Na Intake
- Profiling and Integrated Analysis of the ERCC6-regulated circRNA-miRNA-mRNA Network in Lens Epithelial Cells
- The aging mouse lens transcriptome
- Knockdown of KCNQ1OT1 Alleviates the Activation of NLRP3 Inflammasome Through miR-17-5p/TXNIP Axis in Retinal Müller Cells
- Knockdown of lncRNA TUG1 protects lens epithelial cells from oxidative stress-induced injury by regulating miR-196a-5p expression in age-related cataracts
- Identification of key genes involved in Brg1 mutation-induced cataract using bioinformatics analyses with publicly available microarray data.
- Mechanism of M2 macrophage-derived extracellular vesicles carrying lncRNA MEG3 in inflammatory responses in ulcerative colitis
- Role of long noncoding RNA KCNQ1 overlapping transcript 1/microRNA-124-3p/BCL-2-like 11 axis in hydrogen peroxide (H2O2)-stimulated human lens epithelial cells
- MiR-34a-5p Negatively Regulates Oxidative Stress on Lens Epithelial Cells by Silencing GPX3 – A Novel Target
- Reactive Oxygen Species and Eye Aging in Cataracts through Biomolecular Mechanisms
- High MST2 expression regulates lens epithelial cell apoptosis in age-related cataracts through YAP1 targeting GLUT1.
- Noncoding RNAs in cataract formation: star molecules emerge in an endless stream.
- Exosomal microRNA-222-3p increases UVB sensitivity of lens epithelium cells by suppressing MGMT
- ceRNA network construction and identification of hub genes as novel therapeutic targets for age-related cataracts using bioinformatics
- Long non-coding RNA nuclear paraspeckle assembly transcript 1 downregulation protects lens epithelial cells from oxidative stress-induced apoptosis by regulating the microRNA-124-3p/death-associated protein kinase 1 axis in age-related cataract
- Cataractogenesis and molecular pathways with reactive free oxygen species as a common pathway.
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