A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications.
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Summary
The current understanding of the molecular mechanisms involved in pyroptosis, as well as recent advances in the role of NLRP3 inflammasome activation and pyroPTosis in the development of diabetes and diabetic complications are summarized.
- Type
- review
- Published
- 2019-12-03
- Cited by
- 175
- References
- 109
- OpenAlex
- https://openalex.org/W2991708020
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:208814551
Keywords
Pyroptosis, Inflammasome, Caspase 1, Diabetes mellitus, Medicine
References
- Research progress in signalling pathway in diabetic nephropathy
- Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens
- Genetic variation in pattern recognition receptors: functional consequences and susceptibility to infectious disease.
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation
- Responses of Multipotent Retinal Stem Cells to IL-1β, IL-18, or IL-17
- MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy
- Caspase‐1‐dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages
- The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
- Correlation of plasma resistin with obesity and insulin resistance in type 2 diabetic patients.
- Tyrosine Phosphatase Inhibition Induces an ASC-dependent Pyroptosis
- The NAIP–NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus
- NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model
- Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection
- Inflammasomes in health and disease
- Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
- NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration.
- Initiation and perpetuation of NLRP3 inflammasome activation and assembly
- Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
Cited by
- Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats
- Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway
- Inflammasomes and Proteostasis Novel Molecular Mechanisms Associated With Atrial Fibrillation
- Zhen-Wu-Tang Protects IgA Nephropathy in Rats by Regulating Exosomes to Inhibit NF-κB/NLRP3 Pathway
- Role of pyroptosis in spinal cord injury and its therapeutic implications
- Sinomenine Alleviates Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis through Inhibiting NLRP3 Inflammasome
- Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation
- miRNA-141 Induced Pyroptosis in Intervertebral Disk Degeneration by Targeting ROS Generation and Activating TXNIP/NLRP3 Signaling in Nucleus Pulpous Cells
- The NLRP3 Inflammasome and Its Role in T1DM
- Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ‐induced diabetic mice
- Endoplasmic reticulum stress related factor IRE1α regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy.
- New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease
- USF2 knockdown downregulates THBS1 to inhibit the TGF-β signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury.
- Stem Cell-Derived Exosomes Ameliorate Doxorubicin-Induced Muscle Toxicity through Counteracting Pyroptosis
- Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond
- The NLRP3 inflammasome: Multiple activation pathways and its role in primary cells during ventricular remodeling
- IP3R1 regulates Ca2+ transport and pyroptosis through the NLRP3/Caspase-1 pathway in myocardial ischemia/reperfusion injury
- Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis
- Exploring the recent molecular targets for diabetes and associated complications
- Potential of Forsythoside I as a therapeutic approach for acute lung injury: Involvement of TXNIP/NLRP3 inflammasome.
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