New treatments for osteoarthritis must be based on evidence.
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Summary
A lack of evidence for any clinically significant delayed response to treatment up to 1 year is suggested from these extended follow-up data, and a potential mech anism of action could be by reduction of inflammation in soft tissue and particularly synovial inflammation seen in many patients with the condition.
- Type
- article
- Published
- 2020-01-01
- Cited by
- 0
- References
- 10
- Access
- Open access
- OpenAlex
- https://openalex.org/W2989665958
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:213930650
Keywords
Osteoarthritis, Medicine, Clinical trial, Physical therapy, Rheumatology
References
- SYNOVITIS IN KNEE OSTEOARTHRITIS: A PRECURSOR OF DISEASE?
- Relation of synovitis to knee pain using contrast-enhanced MRIs
- The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials
- Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis
- Lack of beneficial effects of low-dose radiation therapy on hand osteoarthritis symptoms and inflammation: a randomised, blinded, sham-controlled trial.
- Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial
- Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis: a randomised, double-blinded, sham-controlled trial
- Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis
- OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis.
- Long-term efficacy of low-dose radiation therapy on symptoms in patients with knee and hand osteoarthritis: follow-up results of two parallel randomised, sham-controlled trials.
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