Biphenyl Acid Derivatives as APJ Receptor Agonists.
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Summary
The discovery of a series of biphenyl acid derivatives as potent APJ receptor agonists is described, following the identification of initial high-throughput screen lead 2, and successive optimization led to the discovery of lead compound 15a.
- Type
- article
- Published
- 2019-11-14
- Cited by
- 19
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W2987523875
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:208017491
Keywords
Chemistry, Apelin, Receptor, Pharmacology, In vivo
References
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Cited by
- A patent review of apelin receptor (APJR) modulators (2014-2019)
- Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system
- Development of Two Synthetic Approaches to an APJ Receptor Agonist Containing a Tetra-ortho-Substituted Biaryl Pyridone
- Identification of 6-Hydroxypyrimidin-4(1H)-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists.
- Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure.
- Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor.
- Design and preparation of N-linked hydroxypyridine-based APJ agonists.
- Recent progress toward developing axial chirality bioactive compounds.
- Structure–function relationship and physiological role of apelin and its G protein coupled receptor
- Isolation, synthesis and medicinal chemistry of biphenyl analogs – A review
- Organocatalytic olefin C–H functionalization for enantioselective synthesis of atropisomeric 1,3-dienes
- Bioactive atropisomers: Unraveling design strategies and synthetic routes for drug discovery
- Palladium-catalyzed ligand for sterically enabled nondirected distal-selective C-H arylation of arenes
- Molecular docking and SARs guiding the gradual development of thiazole‐2‐yl amide derivatives containing biphenyl groups as promising antifungal scaffolds
- Apelin receptor in GtoPdb v.2025.3
- The Apelinergic System in Kidney Disease: Novel Perspectives
- International Union of Basic and Clinical Pharmacology. CXXI. Apelin receptor pharmacology in the human cardiovascular system and emerging clinical applications
- Application in Drugs and Materials
- Apelin receptor in GtoPdb v.2023.1 Apelin receptor in GtoPdb v.2023.1
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