Vascular AMPK: enhancer, brake or both?
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Summary
The contribution of endothelial AMPK in the regulation of vascular tone, in particular in the microvasculature where EDH plays a more important role, remains to be characterized.
- Type
- review
- Published
- 2019-11-24
- Cited by
- 9
- References
- 98
- Access
- Open access
- OpenAlex
- https://openalex.org/W2986372585
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:214270187
Keywords
AMPK, AMP-activated protein kinase, Vasodilation, Protein kinase A, Endocrinology
References
- Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric oxide availability in essential hypertensive patients.
- Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
- PKC and AMPK regulation of Kv1.5 potassium channels
- Perivascular fat, AMP‐activated protein kinase and vascular diseases
- Reduced activity of SKCa and Na-K ATPase underlies the accelerated impairment of EDH-type relaxations in mesenteric arteries of aging spontaneously hypertensive rats
- K+ is an endothelium-derived hyperpolarizing factor in rat arteries
- Endothelium‐dependent contractions: when a good guy turns bad!
- The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation: Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies
- Globular adiponectin controls insulin-mediated vasoreactivity in muscle through AMPKα2.
- Effects of methyl β‐cyclodextrin on EDHF responses in pig and rat arteries; association between SKCa channels and caveolin‐rich domains
- Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: involvement of myocyte BKCa channels and adiponectin
- Long-term Effects of Lifestyle Intervention or Metformin on Diabetes Development and Microvascular Complications: the DPP Outcomes Study
- AMPKα2 deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction in vivo: Role of 26S Proteasomes
- Characterization of the endothelium-derived hyperpolarizing factor (EDHF) response in the human interlobar artery.
- AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633
- AMP-ACTIVATED PROTEIN KINASE MEDIATES CAROTID BODY EXCITATION BY HYPOXIA
- Intravenous AICAR During Hyperinsulinemia Induces Systemic Hemodynamic Changes but Has No Local Metabolic Effect
- Direct Activation of AMP-activated Protein Kinase Stimulates Nitric-oxide Synthesis in Human Aortic Endothelial Cells*
- Salt-inducible kinase 1 influences Na+,K+-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure
- Role of Caveolar Compartmentation in Endothelium-Derived Hyperpolarizing Factor–Mediated Relaxation: Ca2+ Signals and Gap Junction Function Are Regulated by Caveolin in Endothelial Cells
Cited by
- Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol.
- Cerebrovascular Blood Flow Design and Regulation; Vulnerability in Aging Brain
- Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?
- Resistance artery vasodilator pathways involved in the antihypertensive effects of cocoa shell extract in rats exposed to fetal undernutrition
- Sex-Specific Cardiovascular Protection in Developing Metabolic Syndrome: The Role of AMPK
- Paeoniflorin mitigates myocardial hypertrophy by regulating mitophagy and ferroptosis mediated by mitochondria-associated AMPK-Parkin-ACSL4 pathway.
- Mechanisms of Vasodilatation/Endothelium‐dependent Hyperpolarization (MOVD/EDH) 2019—Rotterdam, The Netherlands
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