Az adoptív sejttranszfer sikere a hematológiában: a kiméra antigénreceptorral felruházott T-sejtek
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Summary
The aim of this review is to describe the present CAR-T repertoire and to outline the therapeutic challenges and the potential solutions thereby allowing a better understanding of the most promising pillar of tumor therapy.
- Type
- article
- Published
- 2019-09-01
- Cited by
- 0
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W2980747174
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:213489687
Keywords
Medicine, Internal medicine, Gynecology, Gastroenterology
References
- The pharmacology of second-generation chimeric antigen receptors
- Functional Comparison of Engineered T Cells Carrying a Native TCR versus TCR-like Antibody–Based Chimeric Antigen Receptors Indicates Affinity/Avidity Thresholds
- Engineering CAR-T Cells: Design Concepts
- A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)
- Cancer immunoediting: from immunosurveillance to tumor escape
- Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
- Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
- TRUCKs: the fourth generation of CARs
- Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor.
- Beyond CD19: Opportunities for Future Development of Targeted Immunotherapy in Pediatric Relapsed-Refractory Acute Leukemia
- Impaired induction of the CD28-responsive complex in granulocyte colony-stimulating factor mobilized CD4 T cells.
- Current Status of Immunotherapy
- Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia.
- Chimeric Antigen Receptor T-Cell Therapy for the Community Oncologist.
- Randomized, Phase II Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells Directed Against CD19 (CTL019) in Patients with Relapsed, Refractory CLL
- T cells expressing CD19/CD20 bi-specific chimeric antigen receptors prevent antigen escape by malignant B cells
- Newer treatments for non-Hodgkin's lymphoma: monoclonal antibodies.
- Unicar: A Novel Modular Retargeting Platform Technology for CAR T Cells
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