Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis.
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Summary
Omics studies using liquid chromatography-orbitrap mass spectrometry to depict the possible contribution of BDE-47 exposure to PD pathology and highlights the powerfulness of omics platforms to deepen the mechanistic understanding of environmental pollutant-caused toxicity.
- Type
- article
- Published
- 2019-10-15
- Cited by
- 45
- References
- 54
- OpenAlex
- https://openalex.org/W2951903539
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:189943905
Keywords
Polybrominated diphenyl ethers, Metabolomics, Oxidative stress, Metabolite, Chemistry
References
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- Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants
- The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson’s disease: a review of in vivo models
- Targeting adenosine A2A receptors in Parkinson's disease.
- Polychlorinated Biphenyls and Neurodegenerative Disease Mortality in an Occupational Cohort
- Neurotoxicity of Brominated Flame Retardants: (In)direct Effects of Parent and Hydroxylated Polybrominated Diphenyl Ethers on the (Developing) Nervous System
- Changes of voltage‐dependent anion‐selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down Syndrome
- Distribution of Serotonin-immunoreactive Enterochromaffin Cells in the Gastrointestinal Tract of the Least Shrew (Cryptotis parva)
- Synaptic dysfunction and septin protein family members in neurodegenerative diseases
- Association between polychlorinated biphenyls and Parkinson’s disease neuropathology
- Standard Operating Procedures for Serum and Plasma Collection: Early Detection Research Network Consensus Statement Standard Operating Procedure Integration Working Group
- Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
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- Mechanisms of dopamine transporter regulation in normal and disease states
Cited by
- Study of metabolic disorders associated with BDE-47 exposure in Drosophila model by MS-based metabolomics.
- 6-OH-BDE-47 exposure-induced Parkinson's disease pathology in Sprague Dawley rat.
- Integration of proteomics and metabolomics reveals promotion of proliferation by exposure of bisphenol S in human breast epithelial MCF-10A cells.
- CPVA: a web-based metabolomic tool for chromatographic peak visualization and annotation
- A comprehensive analysis of metabolomics and transcriptomics reveals new biomarkers and mechanistic insights on DEHP exposures in MCF-7 cells.
- Lipidomics and environmental toxicology: Recent trends
- BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling.
- 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces wide metabolic changes including attenuated mitochondrial function and enhanced glycolysis in PC12 cells.
- Neurotoxicity assessment of triazole fungicides on mitochondrial oxidative respiration and lipids in differentiated human SH-SY5Y neuroblastoma cells.
- Interaction of BDE-47 with nuclear receptors (NRs) based on the cytotoxicity: In vitro investigation and molecular interaction.
- Early life exposure to environmental contaminants (BDE-47, TBBPA, and BPS) produced persistent alterations in fecal microbiome in adult male mice.
- Systems biology approaches to study lipidomes in health and disease.
- Long-term exposure to 2-amino-3-methylimidazo[4,5-f]quinoline can trigger a potential risk of Parkinson's disease.
- Ecological and toxicological assessments of anthropogenic contaminants based on environmental metabolomics
- Integrated Proteomics and Metabolomics Assessment Indicated Metabolic Alterations in Hypothalamus of Mice Exposed to Triclosan.
- Comprehensive multi-omics approaches reveal the hepatotoxic mechanism of perfluorohexanoic acid (PFHxA) in mice.
- Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms
- TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion.
- Serum metabolomic and lipidomic profiling identifies diagnostic biomarkers for seropositive and seronegative rheumatoid arthritis patients
- First insights into the honey bee (Apis mellifera) brain lipidome and its neonicotinoid-induced alterations associated with reduced self-grooming behavior
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