Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition
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Summary
It is shown that serum-deprived mesenchymal stem cells produce exosomes up to 22-fold more effective at delivering siRNAs to neurons than exosome derived from control cells.
- Type
- article
- Published
- 2019-05-27
- Cited by
- 92
- References
- 73
- Access
- Open access
- OpenAlex
- https://openalex.org/W2947838112
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:189817976
Keywords
Microvesicles, Exosome, Mesenchymal stem cell, Cell biology, Small interfering RNA
References
- Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein
- NIH Image to ImageJ: 25 years of Image Analysis
- In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior
- Lipid Metabolism and Regulation of Membrane Trafficking
- Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
- Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
- Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
- Serum-deprived human multipotent mesenchymal stromal cells (MSCs) are highly angiogenic
- T lymphocytes export proteasomes by way of microparticles: a possible mechanism for generation of extracellular proteasomes
- Multivesicular Bodies as a Platform for Formation of the Marburg Virus Envelope
- Shotgun Lipidomics by Sequential Precursor Ion Fragmentation on a Hybrid Quadrupole Time-of-Flight Mass Spectrometer
- A Novel Cardiolipin-remodeling Pathway Revealed by a Gene Encoding an Endoplasmic Reticulum-associated Acyl-CoA:Lysocardiolipin Acyltransferase (ALCAT1) in Mouse*
- Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells
- Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi.
- Serum deprivation elevates the levels of microvesicles with different size distributions and selectively enriched proteins in human myeloma cells in vitro
- Fetuin-A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading
- Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome
- Dynamic Biodistribution of Extracellular Vesicles In Vivo Using a Multimodal Imaging Reporter
- The mechanism of acyl specific phospholipid remodeling by tafazzin
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Cited by
- Emerging Role of Extracellular Vesicles in Liver Diseases.
- Angiogenic Effects of Human Dental Pulp and Bone Marrow-Derived Mesenchymal Stromal Cells and their Extracellular Vesicles
- Urinary exosomes protein cargo as biomarkers of Autosomal Dominant Polycystic Kidney Disease (ADPKD)
- Mesenchymal Stem Cell–Derived Extracellular Vesicles Alleviate Acute Lung Injury Via Transfer of miR-27a-3p*
- RNA delivery by extracellular vesicles in mammalian cells and its applications
- Biomimetic nanovesicle design for cardiac tissue repair.
- Strategies for scalable manufacturing and translation of MSC-derived extracellular vesicles.
- Immunosuppressive Effects of Mesenchymal Stem Cells-derived Exosomes
- Improving hematopoietic engraftment: Potential role of mesenchymal stromal cell‐derived extracellular vesicles
- Surface-Enhanced Raman Spectroscopy as a Tool for Distinguishing Extracellular Vesicles under Autophagic Conditions: A Marker for Disease Diagnostics.
- Anchor, Spacer, and Ligand-Modified Engineered Exosomes for Trackable Targeted Therapy.
- Glycosylation of Cancer Extracellular Vesicles: Capture Strategies, Functional Roles and Potential Clinical Applications
- The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Autoimmune Disorders
- Recent Progress of Exosomes in Multiple Myeloma: Pathogenesis, Diagnosis, Prognosis and Therapeutic Strategies
- Palladium Nanoparticle-Induced Oxidative Stress, Endoplasmic Reticulum Stress, Apoptosis, and Immunomodulation Enhance the Biogenesis and Release of Exosome in Human Leukemia Monocytic Cells (THP-1)
- Comparative Analysis of MSC-Derived Exosomes Depending on Cell Culture Media for Regenerative Bioactivity
- A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem Cells
- Conditioned media from human adipose-derived stem cell culture in some stressed culture conditions differ angiogenic potential
- Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy
- Potential of Human Wharton’s Jelly Mesenchymal Stem Cells (hWJMSCs) Secretome for COVID-19 Adjuvant Therapy Candidate
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