Structural and free energy landscape of novel mutations in ribosomal protein S1 (rpsA) associated with pyrazinamide resistance
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Summary
Investigating the molecular mechanism of resistance behind mutations, D342N, D343N, A344P, and I351F, present in the MtRpsACTD through molecular dynamic simulations (MD) may provide a better insight into the resistance mechanism to achieve the global TB control targets.
- Type
- article
- Published
- 2019-05-16
- Cited by
- 76
- References
- 89
- Access
- Open access
- OpenAlex
- https://openalex.org/W2946526111
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:155104433
Keywords
Pyrazinamide, Genetics, Mutant, Gene, Biology
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- Marine Natural Products and Drug Resistance in Latent Tuberculosis
- Molecular dynamics simulation of zika virus NS5 RNA dependent RNA polymerase with selected novel non-nucleoside inhibitors
- Dynamics Insights Into the Gain of Flexibility by Helix-12 in ESR1 as a Mechanism of Resistance to Drugs in Breast Cancer Cell Lines
- Gibbs Free Energy Calculation of Mutation in PncA and RpsA Associated With Pyrazinamide Resistance
- Bioinformatic and computational analysis for predominant mutations of the Nrf2/Keap1 complex in pediatric leukemia
- Mechanistic analysis of A46V, H57Y, and D129N in pyrazinamidase associated with pyrazinamide resistance
- Pyrazinamide resistance of novel mutations in pncA and their dynamic behavior
- Inhibitory insights of strawberry (Fragaria × ananassa var. Seolhyang) root extract on tyrosinase activity using computational and in vitro analysis.
- Isolation, Molecular Typing, and Antibiotic Susceptibility Testing of Mycobacterium avium Subspecies hominissuis From a Dog With Generalized Mycobacteriosis
- Core amino acid substitutions in HCV-3a isolates from Pakistan and opportunities for multi-epitopic vaccines
- Proteome wide vaccine targets prioritization and designing of antigenic vaccine candidate to trigger the host immune response against the Mycoplasma genitalium infection.
- Higher infectivity of the SARS‐CoV‐2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data
- Genome-wide screening of vaccine targets prioritization and reverse vaccinology aided design of peptides vaccine to enforce humoral immune response against Campylobacter jejuni
- Elucidating the Antimycobacterial Mechanism of Action of Ciprofloxacin Using Metabolomics
- Immunogenomics guided design of immunomodulatory multi-epitope subunit vaccine against the SARS-CoV-2 new variants, and its validation through in silico cloning and immune simulation
- Computational Modeling of Immune Response Triggering Immunogenic Peptide Vaccine Against the Human Papillomaviruses to Induce Immunity Against Cervical Cancer
- Structural and Biophysical Investigation of the Key Hotspots on the Surface of Epstein–Barr Nuclear Antigen 1 Essential for DNA Recognition and Pathogenesis
- Mutations in SARS-CoV-2 ORF8 Altered the Bonding Network With Interferon Regulatory Factor 3 to Evade Host Immune System
- Characterization of rifampicin-resistant Mycobacterium tuberculosis in Khyber Pakhtunkhwa, Pakistan
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