Cortical Foxp2 supports behavioral flexibility and developmental dopamine D1 receptor expression
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Summary
A role for Foxp2 in the development of dopamine-modulated cortical circuits and behaviors relevant to neurodevelopmental disorders is supported and alterations included non-cell-autonomous changes in upper-layer neurons and interneurons are found.
- Type
- preprint
- Published
- 2019-05-02
- Cited by
- 42
- References
- 109
- Access
- Open access
- OpenAlex
- https://openalex.org/W2943520911
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:155774901
Keywords
FOXP2, Neuroscience, Dopamine, Cortex (anatomy), Biology
References
- Generation of mice with a conditional Foxp2 null allele
- Prefrontal cortex and hippocampus in behavioural flexibility and posttraumatic functional recovery: reversal learning and set-shifting in rats.
- Visualization of corticofugal projections during early cortical development in a τ‐GFP‐transgenic mouse
- FoxP2 protein levels regulate cell morphology changes and migration patterns in the vertebrate developing telencephalon
- REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms
- Guidance of instrumental behavior under reversal conditions requires dopamine D1 and D2 receptor activation in the orbitofrontal cortex.
- Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene.
- Genetic targeting of principal neurons in neocortex and hippocampus of NEX‐Cre mice
- Dopamine Receptor Activation Modulates GABA Neuron Migration from the Basal Forebrain to the Cerebral Cortex
- Impaired Synaptic Plasticity and Motor Learning in Mice with a Point Mutation Implicated in Human Speech Deficits
- Developmental origins of brain disorders: roles for dopamine
- Activation of Phosphatidylinositol-linked Novel D1 Dopamine Receptor Contributes to the Calcium Mobilization in Cultured Rat Prefrontal Cortical Astrocytes
- Transient D1Dopamine Receptor Expression on Prefrontal Cortex Projection Neurons: Relationship to Enhanced Motivational Salience of Drug Cues in Adolescence
- FOXP2 and the neuroanatomy of speech and language
- The structure of innate vocalizations in Foxp2-deficient mouse pups
- The human language and epilepsy associated gene SRPX2 regulates synapse formation and vocalization in mice
- Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism
- Foxp2 Regulates Gene Networks Implicated in Neurite Outgrowth in the Developing Brain
- Ultrasonic vocalization in rat pups: effects of early postnatal exposure to SCH 23390 (a DA1-receptor antagonist) and sulpiride (a DA2-receptor antagonist).
- Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality
Cited by
- Chromatin decondensation by FOXP2 promotes human neuron maturation and expression of neurodevelopmental disease genes
- FOXP transcription factors in vertebrate brain development, function, and disorders
- Genetic dissection of glutamatergic neuron subpopulations and developmental trajectories in the cerebral cortex
- Genetic pathways involved in human speech disorders.
- Behavior-related gene regulatory networks: A new level of organization in the brain
- Zbtb16 regulates social cognitive behaviors and neocortical development
- Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids
- Region-specific Foxp2 deletions in cortex, striatum or cerebellum cannot explain vocalization deficits observed in spontaneous global knockouts
- Interactome, Network, and Enrichment Motif Analysis Reveals Possible Linkage Between Human Mental Disorders, Emotions, and Coronavirus: In-Silico Insight
- Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex
- Molecular networks of the FOXP2 transcription factor in the brain
- Dissecting the neurobiology of linguistic disorganisation and impoverishment in schizophrenia.
- Confronting false discoveries in single-cell differential expression
- Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish—implications for neurodevelopmental disorders
- Contributions of common genetic variants to specific languages and to when a language is learned
- Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD
- Genomic Strategies for Understanding the Pathophysiology of Autism Spectrum Disorder
- FOXP2 down expression is associated with executive dysfunctions and electrophysiological abnormalities of brain in Autism spectrum disorder; a neuroimaging genetic study
- Adolescent alcohol exposure reduces dopamine 1 receptor modulation of prelimbic neurons projecting to the nucleus accumbens and basolateral amygdala
- Distinct prefrontal projections conversely orchestrate social competition and hierarchy
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