E3 ligase ASB8 promotes porcine reproductive and respiratory syndrome virus proliferation by stabilizing the viral Nsp1α protein and degrading host IKKβ kinase.
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Summary
This study demonstrated that PRRSV Nsp1α interacted with the host E3 ubiquitin ligase ankyrin repeat and SOCS box-containing 8 and hijacked up-regulated host ASB8 to escape from intrinsic antiviral immunity.
- Type
- article
- Published
- 2019-04-15
- Cited by
- 28
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W2938843390
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:128361851
Keywords
Porcine reproductive and respiratory syndrome virus, Ubiquitin ligase, Biology, Ubiquitin, IκB kinase
References
- Degradation of CREB-binding protein and modulation of type I interferon induction by the zinc finger motif of the porcine reproductive and respiratory syndrome virus nsp1α subunit.
- The nonstructural protein 11 of porcine reproductive and respiratory syndrome virus inhibits NF-κB signaling by means of its deubiquitinating activity
- Interplay between the virus and the ubiquitin–proteasome system: molecular mechanism of viral pathogenesis
- Recognition of nucleic acids by pattern‐recognition receptors and its relevance in autoimmunity
- TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase
- IκB kinase complexes: gateways to NF-κB activation and transcription
- The Transmembrane E3 Ligase GRAIL Ubiquitinates and Degrades CD83 on CD4 T Cells
- Ubiquitination in the Antiviral Immune Response
- SOCS Proteins: Negative Regulators of Cytokine Signaling
- The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
- Complete Genome Sequence of a Novel Variant Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Strain: Evidence for Recombination between Vaccine and Wild-Type PRRSV Strains
- Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation
- Porcine Reproductive and Respiratory Syndrome Virus Induces Interleukin-15 through the NF-κB Signaling Pathway
- Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development
- ASB2 Is an Elongin BC-interacting Protein That Can Assemble with Cullin 5 and Rbx1 to Reconstitute an E3 Ubiquitin Ligase Complex*
- TRIM22 Inhibits Influenza A Virus Infection by Targeting the Viral Nucleoprotein for Degradation
- Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells
- Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection
- Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A
- Antagonizing Interferon-Mediated Immune Response by Porcine Reproductive and Respiratory Syndrome Virus
Cited by
- Phytohormonal cross-talk modulate Bipolaris sorokiniana (Scc.)interaction with Zea mays
- E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis.
- Cullin-RING Ligase 5: Functional characterization and its role in human cancers.
- The Vif protein of caprine arthritis encephalitis virus inhibits interferon production
- E2 ubiquitin-conjugating enzyme UBE2L6 promotes Senecavirus A proliferation by stabilizing the viral RNA polymerase
- The ubiquitin proteasome system is necessary for efficient proliferation of porcine reproductive and respiratory syndrome virus.
- TRAF6 autophagic degradation by avibirnavirus VP3 inhibits antiviral innate immunity via blocking NFKB/NF-κB activation
- Research Progress in Porcine Reproductive and Respiratory Syndrome Virus–Host Protein Interactions
- Regulation of cGAS/STING signaling and corresponding immune escape strategies of viruses
- N-Acetyltransferase 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Proliferation by N-Terminal Acetylation of the Structural Protein GP5
- E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1.
- Variations in NSP1 of Porcine Reproductive and Respiratory Syndrome Virus Isolated in China from 1996 to 2022
- One-Step Assembly of a PRRSV Infectious cDNA Clone and a Convenient CRISPR/Cas9-Based Gene-Editing Technology for Manipulation of PRRSV Genome
- The Identification of Host Proteins That Interact with Non-Structural Proteins-1α and -1β of Porcine Reproductive and Respiratory Syndrome Virus-1
- Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma
- PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity
- ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota
- Research progress on the molecular mechanism of immune escape of porcine reproductive and respiratory syndrome virus.
- Understanding Post-Translational Modifications in Porcine Reproductive and Respiratory Syndrome Virus Infection
- The Strategies Used by Animal Viruses to Antagonize Host Antiviral Innate Immunity: New Clues for Developing Live Attenuated Vaccines (LAVs)
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