Targeting Macrophage for the Treatment of Amyotrophic Lateral Sclerosis.
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Summary
Modulation of macrophage activation states may stabilize neuromuscular junction and provide protection against motor neuron degeneration in amyotrophic lateral sclerosis.
- Type
- review
- Published
- 2019-04-09
- Cited by
- 3
- References
- 79
- OpenAlex
- https://openalex.org/W2938751847
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:104296598
Keywords
Amyotrophic lateral sclerosis, Macrophage, Medicine, Neuroscience, Biology
References
- Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells
- Sporadic and hereditary amyotrophic lateral sclerosis (ALS).
- Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications
- Tocilizumab attenuates inflammation in ALS patients through inhibition of IL6 receptor signaling.
- Inflammation Induces TDP-43 Mislocalization and Aggregation
- Restricted Expression of G86R Cu/Zn Superoxide Dismutase in Astrocytes Results in Astrocytosis But Does Not Cause Motoneuron Degeneration
- Randomized phase 2 trial of NP001–a novel immune regulator: Safety and early efficacy in ALS
- Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase.
- The “Dying-Back” Phenomenon of Motor Neurons in ALS
- The inhibitory neurotransmitter glycine modulates macrophage activity by activation of neutral amino acid transporters
- Motor neuron–immune interactions: the vicious circle of ALS
- Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.
- Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis
- MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS).
- In Vivo Imaging Reveals Distinct Inflammatory Activity of CNS Microglia versus PNS Macrophages in a Mouse Model for ALS
- Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance
- Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis
- Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
- Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice
- Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis
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