CAR T Cell Toxicity: Current Management and Future Directions
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Summary
A practical guide for the recognition and management of the most important toxicities related to the use of the current commercial CAR T cells is offered, and strategies to diminish these side effects in the future are highlighted.
- Type
- review
- Published
- 2019-03-29
- Cited by
- 140
- References
- 72
- Access
- Open access
- OpenAlex
- https://openalex.org/W2933778904
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:133541148
Keywords
Lymphoma, Follicular lymphoma, Chimeric antigen receptor, Medicine, Oncology
References
- Fast Cars and No Brakes: Autologous Stem Cell Transplantation as a Platform for Novel Immunotherapies
- Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19.
- The influence of cytokines on the integrity of the blood-brain barrier in vitro.
- Managing Cytokine Release Syndrome Associated With Novel T Cell-Engaging Therapies
- Astrocyte–endothelial interactions at the blood–brain barrier
- Effect of dimethylsulfoxide on the functions of mesenchymal and hemopoietic precursors
- CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia
- Graft-versus-Host Disease
- Exploring the full spectrum of macrophage activation
- Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice.
- Current concepts in the diagnosis and management of cytokine release syndrome.
- Increased angiopoietin2 expression is associated with endothelial apoptosis and blood–brain barrier breakdown
- Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
- Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
- Tumor lysis syndrome in the era of novel and targeted agents in patients with hematologic malignancies: a systematic review
- Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease.
- Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia.
- Toxicity and management in CAR T-cell therapy
Cited by
- Chimeric Antigen Receptor (CAR) T-Cell Therapy.
- Polyampholytes as Emerging Macromolecular Cryoprotectants
- Recent Advances in CAR-T Cell Therapy for Non-Hodgkin Lymphoma.
- The Role of Autologous Stem Cell Transplantation in the Treatment of Diffuse Large B-cell Lymphoma in the Era of CAR-T Cell Therapy
- Engineering T cells for immunotherapy of primary human hepatocellular carcinoma
- CAR T-Cell-Associated Neurotoxicity
- Acute Kidney Injury after CAR-T Cell Therapy: Low Incidence and Rapid Recovery
- Myeloma CAR-T CRS Management With IL-1R Antagonist Anakinra
- Expanding Access to Chimeric Antigen Receptor T-Cell Therapies: Challenges and Opportunities.
- The Advent of CAR T-Cell Therapy for Lymphoproliferative Neoplasms: Integrating Research Into Clinical Practice
- Nursing Management in CAR-T Cell Therapy
- Advances in Anti-Cancer Immunotherapy: Car-T Cell, Checkpoint Inhibitors, Dendritic Cell Vaccines, and Oncolytic Viruses, and Emerging Cellular and Molecular Targets
- Mechanogenetics for Cellular Engineering and Cancer Immunotherapy
- CAR T-Cells in Multiple Myeloma: State of the Art and Future Directions
- A comprehensive review on: Chimeric Antigen Receptor (CAR) T-cell therapy in cancer treatment
- Infection during the first year in patients treated with CD19 CAR T cells for diffuse large B cell lymphoma
- The magic bullet as cancer therapeutic—has nanotechnology failed to find its mark?
- Neurotoxicity and Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy: Insights Into Mechanisms and Novel Therapies
- Targeting FcRn for immunomodulation: Benefits, risks, and practical considerations
- Tisagenlecleucel in Children and Young Adults: Reverse Translational Research by Using Real-World Safety Data
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