Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases
Explore this paper's citation graph
Summary
An overview of microbial SCFAs production and their effects on the intestinal mucosa with specific emphasis on their relevance for Inflammatory Bowel Diseases is presented and the therapeutic potential ofSCFAs for IBD is discussed.
- Type
- review
- Published
- 2019-03-11
- Cited by
- 3,414
- References
- 163
- Access
- Open access
- OpenAlex
- https://openalex.org/W2921966151
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:72941254
Keywords
Immune system, Inflammatory bowel disease, Short-chain fatty acid, Inflammatory Bowel Diseases, Immunology
References
- Short‐chain fatty acid enemas fail to decrease colonic hypersensitivity and inflammation in TNBS‐induced colonic inflammation in rats
- Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity
- Physiological aspects of resistant starch and in vivo measurements.
- Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.
- Dietary Fiber Intake is Associated with Increased Colonic Mucosal GPR43+ Polymorphonuclear Infiltration in Active Crohn’s Disease
- Dietary pectin up‐regulates monocaboxylate transporter 1 in the rat gastrointestinal tract
- Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora
- Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis.
- Intestinal Microbiota in Animal Models of Inflammatory Diseases.
- Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides.
- Remodeling of Tight Junctions and Enhancement of Barrier Integrity of the CACO-2 Intestinal Epithelial Cell Layer by Micronutrients
- Review article: the role of butyrate on colonic function
- New targets for mucosal healing and therapy in inflammatory bowel diseases
- Clostridium butyricum, a probiotic derivative, suppresses dextran sulfate sodium-induced experimental colitis in rats.
- Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis
- Histone deacetylases as regulators of inflammation and immunity.
- Activation of the receptor (Gpr109a) for niacin and the commensal metabolite butyrate suppresses colonic inflammation and carcinogenesis
- G Protein-Coupled Receptor 43 Moderates Gut Inflammation Through Cytokine Regulation from Mononuclear Cells
- Concentration- and pH-dependence of short-chain fatty acid absorption in the proximal and distal colon of guinea pig (Cavia porcellus).
- Short chain fatty acid absorption by the human large intestine.
Cited by
- Risk of colorectal cancer in inflammatory bowel diseases.
- Cecal Infusion of Sodium Propionate Promotes Intestinal Development and Jejunal Barrier Function in Growing Pigs
- A holistic view of gallic acid-induced attenuation in colitis based on microbiome-metabolomics analysis.
- Inflammatory Bowel Disease: A Stressed “Gut/Feeling”
- Endometriosis Pathoetiology and Pathophysiology: Roles of Vitamin A, Estrogen, Immunity, Adipocytes, Gut Microbiome and Melatonergic Pathway on Mitochondria Regulation
- Effects of Copper (Sulfate, Acetate and Nano) in ovo injection on Hatching Traits and some Physiological Parameters of Newly-hatched Broiler Chicks
- Inflammatory and immunometabolic consequences of gut dysfunction in HIV: Parallels with IBD and implications for reservoir persistence and non-AIDS comorbidities
- Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction and malassimilation, which can be partially attenuated by inulin or butyrate.
- The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors
- Microbiota and Immune-Mediated Skin Diseases—An Overview
- Manipulating resident microbiota to enhance regulatory immune function to treat inflammatory bowel diseases
- Chronic Unpredictable Mild Stress in Rats Induces Colonic Inflammation
- Emerging Frontiers in Microbiome Engineering.
- Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice
- Evaluation of the therapeutic activity of Melatonin and Resveratrol in Inflammatory Bowel Disease: a longitudinal PET/CT study in an animal model.
- Low-protein diets supplemented with casein hydrolysate favor the microbiota and enhance the mucosal humoral immunity in the colon of pigs
- Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk
- “Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?
- Applying mass spectrometry-based assays to explore gut microbial metabolism and associations with disease
- Precision Medicine in Inflammatory Bowel Disease
Related papers
- 31288 Occurrence of inflammatory bowel disease in patients with chronic inflammatory skin diseases
- Origins and Directions of Inflammatory Bowel Disease, Early Studies of the “Nonspecific” Inflammatory Bowel Diseases
- Mo1835 PREVALENCE OF OCULAR DISEASES IN INFLAMMATORY BOWEL DISEASE (IBD): A NATIONAL, POPULATION-BASED STUDY
- Bioinspired and biomimetic strategies for inflammatory bowel disease therapy.
- [Inflammatory bowel disease; symptoms and diagnosis of inflammatory bowel diseases].
- Inflammatory bowel disease and inflammatory molecules: Chickens, eggs and therapeutic targets
- Origins and Directions of Inflammatory Bowel Disease, Early Studies of the [ldquo ]Nonspecific[rdquo ] Inflammatory Bowel Diseases
- Proportion of inflammatory bowel diseases patients with suboptimal disease control in daily clinical practice—Real‐world evidence from the inflammatory bowel diseases‐podcast study
- New Medical Therapies in Inflammatory Bowel Diseases In 2017