Autophagy accounts for approximately one-third of mitochondrial protein turnover and is protein selective
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Summary
The work indicates that autophagy acts selectively on mitochondrial proteins, and that most mitochondrial protein turnover occurs through non-autophagic processes.
- Type
- article
- Published
- 2019-03-21
- Cited by
- 45
- References
- 112
- Access
- Open access
- OpenAlex
- https://openalex.org/W2921505376
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:76667649
Keywords
Autophagy, Mitophagy, Parkin, Biology, Mitochondrion
References
- Turnover of rat-liver mitochondria.
- Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila.
- The Temporal Program of Chromosome Replication: Genomewide Replication in clb5Δ Saccharomyces cerevisiae
- Gene: a gene-centered information resource at NCBI
- Turnover of protein and ribonucleic acid in synaptic subcellular fractions from rat brain.
- The metabolism of mitochondrial proteins. 3. The dynamic state of rat liver mitochondria.
- Oxidative stress, mitochondrial dysfunction and the mitochondria theory of aging.
- Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments
- Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis
- Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy
- PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
- Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence.
- Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX.
- Heterogeneity of Mitochondria and Mitochondrial Function within Cells as Another Level of Mitochondrial Complexity
- Surface and inside volumes in globular proteins
- Mitochondrial Fission, Fusion, and Stress
- Proteomic parsimony through bipartite graph analysis improves accuracy and transparency.
- Autophagosome formation: core machinery and adaptations
- Mitochondrial quality control in neurodegenerative diseases.
- Using FlyAtlas to identify better Drosophila melanogaster models of human disease
Cited by
- Outstanding Questions in Mitophagy: What we Do and Do Not Know.
- Mitochondria—Striking a balance between host and endosymbiont
- Molecular mechanisms of selective autophagy in Drosophila.
- Phosphorylation of mitochondrial matrix proteins regulates their selective mitophagic degradation
- Detection of mitophagy in mammalian cells, mice, and yeast.
- Utilization of biomarkers as predictors of skeletal muscle mitochondrial content after physiological intervention and in clinical settings.
- Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes
- Proteomic profiling of mitochondrial-derived vesicles in brain reveals enrichment of respiratory complex sub-assemblies and small TIM chaperones
- The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass
- Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression
- Slowed protein turnover in aging Drosophila reflects a shift in cellular priorities.
- Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC
- Comment on “mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC”
- BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis
- TSG101 negatively regulates mitochondrial biogenesis in axons
- In vivo assay and modelling of protein and mitochondrial turnover during aging
- Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation
- Mitochondrial fission, integrity and completion of mitophagy require separable functions of Vps13D in Drosophila neurons
- Managing risky assets - mitophagy in vivo.
- Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
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