Bacteria Engineered to Produce IL22 in Intestine Induce Expression of REG3G to Reduce Ethanol-induced Liver Disease in Mice
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Summary
Ethanol-associated dysbiosis reduces levels of IAA and activation of the AHR to decrease expression of IL-22 in the intestine, leading to reduced expression of REG3G; this results in bacterial translocation to the liver and steatohepatitis.
- Type
- article
- Published
- 2018-11-17
- Cited by
- 310
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W2900595525
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:53951606
Keywords
Bacteria, Ethanol, Microbiology, Liver disease, Disease
References
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- Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
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- RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
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Cited by
- Antimicrobial proteins: intestinal guards to protect against liver disease
- Microbiome as a therapeutic target in alcohol-related liver disease.
- Exploiting Prophage-Mediated Lysis for Biotherapeutic Release by Lactobacillus reuteri
- Indoles: metabolites produced by intestinal bacteria capable of controlling liver disease manifestation
- Intestinal and hepatic microbiota changes associated with chronic ethanol administration in mice
- Probiotics for Alleviating Alcoholic Liver Injury
- Varied doses and chemical forms of selenium supplementation differentially affect mouse intestinal physiology.
- IL-18/IL-18BP and IL-22/IL-22BP: Two interrelated couples with therapeutic potential.
- Microbiome dysbiosis and alcoholic liver disease☆
- Indole-3-Acetic Acid Alleviates Nonalcoholic Fatty Liver Disease in Mice via Attenuation of Hepatic Lipogenesis, and Oxidative and Inflammatory Stress
- Alcohol or Gut Microbiota: Who Is the Guilty?
- Translating the gut microbiome: ready for the clinic?
- Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome
- Prophages in Lactobacillus reuteri Are Associated with Fitness Trade-Offs but Can Increase Competitiveness in the Gut Ecosystem
- Changes in the composition of the human intestinal microbiome in alcohol use disorder: a systematic review
- Roseburia Spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice.
- Second-generation Probiotics Producing IL-22 Increase Survival of Mice After Total Body Irradiation
- Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting
- Genetically Engineered Escherichia coli Nissle 1917 Secreting GLP‐1 Analog Exhibits Potential Antiobesity Effect in High‐Fat Diet‐Induced Obesity Mice
- Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases.
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