Mixed-Effects Association of Single Cells Identifies an Expanded Effector CD4+ T Cell Subset in Rheumatoid Arthritis
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Summary
Mixed-effects regression of single-cell data accounts for confounding variation and reveals an expanded CD4+ T cell population in rheumatoid arthritis patients that was later seen to contract upon treatment, and could be a potentially widely applied tool for the analysis of high-dimensional single- cell data.
- Type
- article
- Published
- 2018-10-17
- Cited by
- 171
- References
- 85
- Access
- Open access
- OpenAlex
- https://openalex.org/W2896246287
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52987296
Keywords
Rheumatoid arthritis, Effector, Immunology, Association (psychology), Arthritis
References
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- Genetics and epigenetics of rheumatoid arthritis
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- Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B cell Development
Cited by
- CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets
- Gene expression profiling in autoimmune diseases : a story of ups and downs
- Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
- Immune Profiling and Precision Medicine in Systemic Lupus Erythematosus
- Immunoprofiling comes of age
- Single-cell technologies — studying rheumatic diseases one cell at a time
- Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
- diffcyt: Differential discovery in high-dimensional cytometry via high-resolution clustering
- On the discovery of subpopulation-specific state transitions from multi-sample multi-condition single-cell RNA sequencing data
- Atherosclerosis in rheumatoid arthritis: associations between anti-cytomegalovirus IgG antibodies, CD4+CD28null T-cells, CD8+CD28null T-cells and intima-media thickness.
- T and B lymphocytes in fibrosis and systemic sclerosis.
- Multimodal single-cell approaches shed light on T cell heterogeneity
- Mass Spectrometry Methods for In Situ Analysis of Clinical Biomolecules
- Pregnancy-related immune suppression leads to altered influenza vaccine recall responses.
- CiteFuse enables multi-modal analysis of CITE-seq data
- Latent factor modelling of scRNA-seq data uncovers novel pathways dysregulated in cell subsets of autoimmune disease patients
- Advances in genetics toward identifying pathogenic cell states of rheumatoid arthritis
- Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis
- Immune monitoring using mass cytometry and related high-dimensional imaging approaches
- Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis.
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