A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine
Explore this paper's citation graph
Summary
This work suggests a hypothetical molecular mechanism for TRPV1 activation, which involves rotation of a conserved asparagine in S6 from a position facing the S4–S5 linker toward the pore, and shows that this proposed molecular mechanism is compatible with the prevailing theory that the selectivity filter acts as a secondary gate in TRpV1.
- Type
- article
- Published
- 2018-10-17
- Cited by
- 29
- References
- 91
- Access
- Open access
- OpenAlex
- https://openalex.org/W2896227629
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52985930
Keywords
Biophysics, Chemistry, Transient receptor potential channel, Asparagine, Linker
References
- TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids
- Conformational Plasticity in the Selectivity Filter of the TRPV2 Ion Channel
- Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation
- GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers
- The capsaicin receptor: a heat-activated ion channel in the pain pathway
- Structural mechanism underlying capsaicin binding and activation of TRPV1 ion channel
- EMRinger: Side-chain-directed model and map validation for 3D Electron Cryomicroscopy
- Molecular mechanisms of nociception
- TRPV1, but not P2X, requires cholesterol for its function and membrane expression in rat nociceptors.
- TRPV1 structures in distinct conformations reveal mechanisms of activation
- Contribution of the Putative Inner-Pore Region to the Gating of the Transient Receptor Potential Vanilloid Subtype 1 Channel (TRPV1)
- Comparison of simple potential functions for simulating liquid water
- Structure of the TRPA1 ion channel suggests regulatory mechanisms
- Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel*
- Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
- Phosphoinositide regulation of TRPV1 revisited
- Crystal structure of a voltage-gated sodium channel in two potentially inactivated states
- Anton 2: Raising the Bar for Performance and Programmability in a Special-Purpose Molecular Dynamics Supercomputer
- VMD: visual molecular dynamics.
- Molecular Determinants of Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2) Binding to Transient Receptor Potential V1 (TRPV1) Channels*
Cited by
- Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity
- Heat activation mechanism of TRPV1: New insights from molecular dynamics simulation
- The contribution of the ankyrin repeat domain of TRPV1 as a thermal module
- A distinct structural mechanism underlies TRPV1 activation by piperine
- Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels.
- Structural basis of temperature sensation by the TRP channel TRPV3
- Structural biology of thermoTRPV channels
- The ion selectivity filter is not an activation gate in TRPV1-3 channels
- Structural insights into the gating mechanisms of TRPV Channels
- Structure and Function of the calcium-selective TRP channel TRPV6
- Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms
- TRP Channels, Conformational Flexibility, and the Lipid Membrane
- Agonist and antagonist diverted twisting motions of single TRPV1 channel
- Targeting thermoTRP ion channels: in silico preclinical approaches and opportunities
- Temperature‐sensitive transient receptor potential vanilloid channels: structural insights into ligand‐dependent activation
- Extracellular cap domain is an essential component of the TRPV1 gating mechanism
- Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review
- Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel
- An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine
- Venom Peptide Toxins Targeting the Outer Pore Region of Transient Receptor Potential Vanilloid 1 in Pain: Implications for Analgesic Drug Development
Related papers
- The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System
- Role of transient receptor potential vanilloid 1 channel in pancreatitis
- TRP channel antagonists for pain--opportunities beyond TRPV1.
- Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells
- Transient Receptor Potential Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) ion channels are expressed and upregulated in response to estrogen in the rat endometrium
- Sa1216 IN PATIENTS WITH HEARTBURN, SUPERFICIAL MUCOSAL AFFERENT NERVES EXPRESS TRANSIENT RECEPTOR POTENTIAL VANILLOID SUBFAMILY MEMBER-1 (TRPV1)
- [Roles of TRPA1 in acute peripheral neuropathy characteristically induced by oxaliplatin].
- How much potential for transient receptor potential channels in the bladder?
- Transient receptor potential ion channels as targets for the discovery of pain therapeutics.