Strategies for Engineering Natural Product Biosynthesis in Fungi.
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Summary
This review briefly describes examples of the engineering of fungal NP biosynthesis at the global, pathway, and enzyme level using in vivo and in vitro approaches and refers to the range of heterologous expression systems available.
- Type
- review
- Published
- 2019-04-01
- Cited by
- 71
- References
- 87
- Access
- Open access
- OpenAlex
- https://openalex.org/W2895939791
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52979490
Keywords
Natural product, Biosynthesis, Computational biology, Metabolic engineering, Synthetic biology
References
- Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid.
- Development of a versatile and conventional technique for gene disruption in filamentous fungi based on CRISPR-Cas9 technology
- Regulation of secondary metabolite production in the fungal tomato pathogen Cladosporium fulvum.
- Kinetic characterisation of the FAD dependent monooxygenase TropB and investigation of its biotransformation potential
- Spatial regulation of a common precursor from two distinct genes generates metabolite diversity
- Accurate prediction of secondary metabolite gene clusters in filamentous fungi
- High-level semi-synthetic production of the potent antimalarial artemisinin
- Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases
- A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster
- Large-Scale Metabolomics Reveals A Complex Response of Aspergillus nidulans to Epigenetic Perturbation
- Distributing a metabolic pathway among a microbial consortium enhances production of natural products
- Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion.
- Native Promoter Strategy for High-Yielding Synthesis and Engineering of Fungal Secondary Metabolites
- Thioesterase Domains of Fungal Nonreducing Polyketide Synthases Act as Decision Gates during Combinatorial Biosynthesis
- Functional Characterization of MpaG′, the O‐Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid
- Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides.
- Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin
- Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products
- Reconstitution of biosynthetic machinery for the synthesis of the highly elaborated indole diterpene penitrem.
- The Genome Portal of the Department of Energy Joint Genome Institute
Cited by
- Mapping the Fungal Battlefield: Using in situ Chemistry and Deletion Mutants to Monitor Interspecific Chemical Interactions Between Fungi
- Nonproteinaceous effectors: the terra incognita of plant-fungal interactions.
- Unearthing fungal chemodiversity and prospects for drug discovery
- The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi.
- Chromatin-dependent regulation of secondary metabolite biosynthesis in fungi: is the picture complete?
- Advances in microbial culturing conditions to activate silent biosynthetic gene clusters for novel metabolite production
- Rewiring cellular metabolism for heterologous biosynthesis of Taxol
- Discovery of Primarolides A and B from Marine Fungus Asteromyces cruciatus Using Osmotic Stress and Treatment with Suberoylanilide Hydroxamic Acid
- Genetic mining of the “dark matter” in fungal natural products
- Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites
- Advanced Strategies for Production of Natural Products in Yeast
- Manganese(II) Oxidizing Bacteria as Whole-Cell Catalyst for β-Keto Ester Oxidation
- Molecular networking assisted discovery and biosynthesis elucidation of the antimicrobial spiroketals epicospirocins.
- Natural Products from Endophytic Fungi Associated with Rubiaceae Species
- Two CRISPR/Cas9 Systems Developed in Thermomyces dupontii and Characterization of Key Gene Functions in Thermolide Biosynthesis and Fungal Adaptation
- Molecules from nature: Reconciling biodiversity conservation and global healthcare imperatives for sustainable use of medicinal plants and fungi
- Cross kingdom analysis of putative quadruplex-forming sequences in fungal genomes: novel antifungal targets to ameliorate fungal pathogenicity?
- Selecting for useful properties of plants and fungi – Novel approaches, opportunities, and challenges
- Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery
- Diverse Taxonomies for Diverse Chemistries: Enhanced Representation of Natural Product Metabolism in UniProtKB
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