Organoid technology and applications in cancer research
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Summary
In conclusion, organoids represent an excellent preclinical model for human tumors, promoting the translation from basic cancer research to clinical practice and its applications in cancer research are summarized.
- Type
- review
- Published
- 2018-09-15
- Cited by
- 306
- References
- 123
- Access
- Open access
- OpenAlex
- https://openalex.org/W2891846853
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52281763
Keywords
Hematology, Organoid, Internal medicine, Oncology, Medicine
References
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- Modeling rotavirus infection and antiviral therapy using primary intestinal organoids.
- Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
- Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models.
- The development of a method for the preparation of rat intestinal epithelial cell primary cultures.
- Single Lgr5 stem cells build cryptvillus structures in vitro without a mesenchymal niche
- Growth and differentiation of aggregating fetal brain cells in a serum-free defined medium
- Self-formation of functional adenohypophysis in three-dimensional culture
- Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
- Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids
- Growth of a rat neuroblastoma cell line in serum-free supplemented medium.
- Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.
- In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
Cited by
- Development of a functional thyroid model based on an organoid culture system.
- Patient-derived organoids: New co-clinical model to predict treatment response in cancer?
- Applicability of tumor spheroids for in vitro chemosensitivity assays
- Organoid technology in disease modelling, drug development, personalized treatment and regeneration medicine
- Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors
- Integrated cancer tissue engineering models for precision medicine
- Neuropathological and genomic characterization of glioblastoma‐induced rat model: How similar is it to humans for targeted therapy?
- A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases
- Bladder organoids: a step towards personalised cancer therapy?
- Drug-adapted cancer cell lines as preclinical models of acquired resistance
- Targeting mTOR for cancer therapy
- Patient-derived organoid culture for 3D culture of colorectal cancer, renal cancer and osteosarcoma
- The Influence of Cell Type and Culture Medium on Determining Cancer Selectivity of Cold Atmospheric Plasma Treatment
- Current Perspectives on Nasopharyngeal Carcinoma.
- Organoids as a Form of Modern Day Silver Lining
- Conditional Reprogramming for Patient-Derived Cancer Models and Next-Generation Living Biobanks
- A 3D heterotypic multicellular tumor spheroid assay platform to discriminate drug effects on stroma versus cancer cells
- Constricted migration is associated with stable 3D genome structure differences in cancer cell
- Modifying the Tumour Microenvironment: Challenges and Future Perspectives for Anticancer Plasma Treatments
- Organoids: Past Learning and Future Directions
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