NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
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Summary
It is shown that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on the regulation of PDGF-B signaling by NCK adaptor proteins.
- Type
- article
- Published
- 2018-08-27
- Cited by
- 79
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W2888429607
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52094803
Keywords
Pericyte, Neovascularization, Pathological, Retinopathy, Medicine
References
- Regional blood flow in the normal and ischemic brain is controlled by arteriolar smooth muscle cell contractility and not by capillary pericytes
- MSFD2A is critical for the formation and function of the blood brain barrier
- Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
- Nck Adapters Are Involved in the Formation of Dorsal Ruffles, Cell Migration, and Rho Signaling Downstream of the Platelet-derived Growth Factor β Receptor*
- PDGF signaling in cells and mice.
- Targeted deletion of Vegfa in adult mice induces vision loss.
- Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke
- Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization
- A novel and simple method for culturing pericytes from mouse brain
- Retinal angiogenesis in development and disease
- Inhibition of Reactive Gliosis Prevents Neovascular Growth in the Mouse Model of Oxygen-Induced Retinopathy
- Capillary pericytes regulate cerebral blood flow in health and disease
- Managing diabetic retinopathy
- From pathobiology to the Targeting of Pericytes for the Treatment of Diabetic Retinopathy
- Tyrosine Phosphatase SHP-2 Is Involved in Regulation of Platelet-derived Growth Factor-induced Migration*
- Endothelial-pericyte interactions in angiogenesis
- Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life.
- Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton
- Pericytes regulate the blood–brain barrier
- A review of anti-VEGF agents for proliferative diabetic retinopathy
Cited by
- Retinoic Acid Regulates Endothelial β-catenin Expression and Pericyte Numbers in the Developing Brain Vasculature
- Defective vascular signaling & prospective therapeutic targets in brain arteriovenous malformations.
- Novel multi-targeted inhibitors suppress ocular neovascularization by regulating unique gene sets.
- The Adaptor Protein Nck1, but not Nck2, Mediates Shear Stress-Induced Endothelial Permeability
- RANKL blockade suppresses pathological angiogenesis and vascular leakage in ischemic retinopathy.
- Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells
- Caspase-8 modulates physiological and pathological angiogenesis during retina development.
- Emerging links between cerebrovascular and neurodegenerative diseases—a special role for pericytes
- Recent Approaches for Angiogenesis in Search of Successful Tissue Engineering and Regeneration.
- VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury
- Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications
- Activated FGF2 signaling pathway in tumor vasculature is essential for acquired resistance to anti-VEGF therapy
- Microfluidics for Angiogenesis Research.
- Selective Plane Illumination Microscopy and Computing Reveal Differential Obliteration of Retinal Vascular Plexuses
- Selective role of Nck1 in atherogenic inflammation and plaque formation
- Nck1, But Not Nck2, Mediates Disturbed Flow‐Induced p21‐Activated Kinase Activation and Endothelial Permeability
- Pericytes in Vascular Development
- A Reservoir of Fibroblasts Promotes Recovery from Limb Ischemia
- Fibrotic Changes and Endothelial-to-Mesenchymal Transition Promoted by VEGFR2 Antagonism Alter the Therapeutic Effects of VEGFA Pathway Blockage in a Mouse Model of Choroidal Neovascularization
- A review of traditional Chinese medicine on treatment of diabetic retinopathy and involved mechanisms.
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