Evidence that the radioprotector effect of ascorbic acid depends on the radiation dose rate.
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Summary
Evidence of a radioprotective effect for all tested concentrations of Aa is provided only when 20’Gy were delivered at 36 Gy/h and only with 25 mM using the 960 Gy/h dose rate.
- Type
- article
- Published
- 2018-09-01
- Cited by
- 24
- References
- 43
- OpenAlex
- https://openalex.org/W2886849257
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:51930062
Keywords
Ascorbic acid, Drosophila melanogaster, Toxicity, Dose rate, Irradiation
References
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- Radiation Protection in Medical Radiography
- Future role of vitamin C in radiation mitigation and its possible applications in manned deep space missions: survival study and the measurement of cell viability
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- Modifying effect of vitamins C, E and beta-carotene against gamma-ray-induced DNA damage in mouse cells.
- Evidence suggesting that chlorophyllin (CHLN) may act as an inhibitor or a promoter of genetic damage induced by chromium(VI) oxide (CrO3) in somatic cells of Drosophila.
- Protection against ionizing radiation by antioxidant nutrients and phytochemicals.
- The role of antioxidants in the chemistry of oxidative stress: A review.
- Ascorbic acid gives different protective effects in human cells exposed to X-rays and heavy ions.
- Vitamin C: poison, prophylactic or panacea?
- DNA damage repair and cardiovascular diseases.
- Antioxidant Activity of Vitamin C in Iron-overloaded Human Plasma*
- Ascorbic acid and its pro-oxidant activity as a therapy for tumours of oral cavity -- a systematic review.
- Oxidative stress and neurodegeneration: where are we now?
- Evidence for the protective effect of ascorbic acid (vitamin C) in treatment with gamma-rays and chromium (VI) oxide (CrO3) in somatic cells of Drosophila.
- Effect of dose-rate and irradiation geometry on the biological response of normal cells and cancer cells under radiotherapeutic conditions.
- Evidence that low concentrations of chlorophyllin (CHLN) increase the genetic damage induced by gamma rays in somatic cells of Drosophila.
- Influence of dietary quercetin on glutathione redox status in mice.
- Antioxidant compound supplementation prevents oxidative damage in a Drosophila model of Parkinson's disease.
Cited by
- Pharmacology of natural radioprotectors
- Relationship between viability and genotoxic effect of gamma rays delivered at different dose rates in somatic cells of Drosophila melanogaster
- Evaluating the effect of low dose rate of gamma rays in germ cells of Drosophila melanogaster
- Radioprotective effect of chloropyllin, protoporphyrin-XI and bilirubin compared with amifostine® in Drosophila melanogaster.
- EPR Investigation of Mix of Sucrose and Ascorbic Acid Irradiated with γ-Rays
- Assessment of early oxidative stress following the use of radiotheranostics agents 177Lu-PSMA for prostate cancer and 177Lu-DOTATATE for neuroendocrine tumors; radioprotective effect of vitamin C.
- The Role of Nutrition in Space Exploration: Implications for Sensorimotor, Cognition, Behavior and the Cerebral Changes due to the Exposure to Radiation, Altered Gravity, and Isolation/Confinement Hazards of Spaceflight.
- Phytochemicals: A potential next generation agent for radioprotection.
- Investigating the attenuating effect of telmisartan against radiation-induced intestinal injury using 18F-FDG micro-PET imaging
- Review of compounds that exhibit radioprotective and/or mitigatory effects after application of diagnostic or therapeutic ionizing radiation
- Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection.
- RADIOPROTECTION AND RADIOSENSITIZATION: A MODERN VIEW ON RADIOMODULATORS IN PHARMACOLOGY
- Fruits and their phytochemicals in mitigating the ill effects of ionizing radiation: review on the existing scientific evidence and way forward.
- The taste of vitamin C in Drosophila
- Ionizing radiation alters functional neurotransmission in Drosophila larvae
- Ռադիոմոդիֆիկացիան ճառագայթային թերապիայում Համառոտ ակնարկ
- Impact of dietary ingredients on radioprotection and radiosensitization: a comprehensive review
- Role of Sterilization on In Situ Gel-Forming Polymer Stability
- Comparison of the effects of copper chlorophyllin, riboxin, indralin and the combined use of glutathione and ascorbic acid on the survival of mice during fractionated X-ray irradiation
- Effect of trolox, riboxin (inosine), and indralin on X-ray induced oxidative stress in A549 cells
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