High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.
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Summary
It is indicated that 20-HETE contributes to HFD-induced obesity, insulin resistance, and impaired insulin signaling, including reduction in insulin receptor tyrosine phosphorylation and increased serineosphorylation of the insulin receptor substrate-1 (IRS-1).
- Type
- article
- Published
- 2018-11-01
- Cited by
- 47
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2886303208
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:51942513
Keywords
Internal medicine, Endocrinology, Hyperinsulinemia, Insulin resistance, Insulin
References
- Eicosanoids in Metabolic Syndrome
- 20-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3β/Glut2 pathway
- Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy.
- 20-Hydroxyeicosatetraenoic acid, a far-reaching autacoid in chronic kidney disease: hypertension and beyond.
- The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis
- The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss
- 20-HETE and EETs in Diabetic Nephropathy: A Novel Mechanistic Pathway
- Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.
- Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
- 20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction.
- 20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans.
- Elevated level of pro-inflammatory eicosanoids and EPC dysfunction in diabetic patients with cardiac ischemia
- The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes.
- Enalapril reverses high-fat diet-induced alterations in cytochrome P450-mediated eicosanoid metabolism.
- Diet-Induced Obesity in Male C57BL/6 Mice Decreases Fertility as a Consequence of Disrupted Blood-Testis Barrier
- 20-Hydroxyeicosatetraenoic Acid Impairs Endothelial Insulin Signaling by Inducing Phosphorylation of the Insulin Receptor Substrate-1 at Ser616
- Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.
- Urinary 20-Hydroxyeicosatetraenoic Acid Is Associated With Endothelial Dysfunction in Humans
- 20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway.
- Inhibition of 20-HETE attenuates diabetes-induced decreases in retinal hemodynamics
Cited by
- Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney, Liver, Lung and Brain: An Emerging Therapeutic Target
- Resveratrol ameliorates high-fat diet-induced insulin resistance and fatty acid oxidation via ATM-AMPK axis in skeletal muscle.
- The effect of western diet on mice brain lipid composition
- Therapeutic approaches to diabetic cardiomyopathy: Targeting the antioxidant pathway.
- Proximal tubular-targeted overexpression of the Cyp4a12-20-HETE synthase promotes salt-sensitive hypertension in male mice.
- A high fat diet with a high C18:0/C16:0 ratio induced worse metabolic and transcriptomic profiles in C57BL/6 mice
- 20-HETE Interferes with Insulin Signaling and Contributes to Obesity-Driven Insulin Resistance
- Deletion of lysophosphatidylcholine acyltransferase3 in myeloid cells worsens hepatic steatosis after a high fat diet.
- The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process
- Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers
- Arachidonic acid inhibits the production of angiotensin-converting enzyme in human primary adipocytes via a NF-κB-dependent pathway
- Alzheimer’s Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models
- Unraveling the role of 12- and 20-HETE in cardiac pathophysiology: G-protein coupled receptors, pharmacological inhibitors and transgenic approaches.
- Uncovering the signalling, structure and function of the 20-HETE-GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75
- Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis
- Study On Oxylipins Metabolomics Components of Follicular Fluid In Infertile Patients With Diminished Ovarian Reserve By UHPLC-MS-MS
- UHPLC-MS-MS analysis of oxylipins metabolomics components of follicular fluid in infertile individuals with diminished ovarian reserve
- Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases
- Blockade of 20-HETE Receptor Lowers Blood Pressure and Alters Vascular Function in Mice with Smooth Muscle-Specific Overexpression of CYP4A12-20-HETE Synthase
- Crisis of the Asian gut: associations among diet, microbiota, and metabolic diseases
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