Low‐molecular‐mass hyaluronan induces pulmonary inflammation by up‐regulation of Mcl‐1 to inhibit neutrophil apoptosis via PI3K/Akt1 pathway
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Summary
The study suggests that LMMHA induced significantly increased levels of inflammatory factors in bronchoalveolar lavage fluid and activation of the PI3K/Akt1 pathway, which up‐regulates the expression of the anti‐apoptotic protein Mcl‐1 and inhibits the activation of caspase‐3, thereby suppressing neutrophil apoptosis to trigger lung inflammation.
- Type
- article
- Published
- 2018-07-26
- Cited by
- 23
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2862970389
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:49685042
Keywords
Bronchoalveolar lavage, Inflammation, Apoptosis, Chemokine, Signal transduction
References
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- Liver dysfunction after lung recruitment manoeuvres during pressure-controlled ventilation in experimental acute respiratory distress
- Role of CD44 and Hyaluronan in Neutrophil Recruitment1
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- IL-17A, But Not IL-17F, Is Indispensable for Airway Vascular Remodeling Induced by Exaggerated Th17 Cell Responses in Prolonged Ovalbumin-Challenged Mice
- The Rise and Fall of Hyaluronan in Respiratory Diseases
- Inhibition of Neutrophil Apoptosis by TLR Agonists in Whole Blood: Involvement of the Phosphoinositide 3-Kinase/Akt and NF-κB Signaling Pathways, Leading to Increased Levels of Mcl-1, A1, and Phosphorylated Bad
- Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages
- Regulation of matrix metalloproteinase‐9 (MMP‐9) in TNF‐stimulated neutrophils: novel pathways for tertiary granule release
- Genetic Polymorphism of Matrix Metalloproteinase Family and Chronic Obstructive Pulmonary Disease Susceptibility: a Meta-analysis
- Hyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4*
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- Matrix-Dependent Mechanism of Neutrophil-Mediated Release and Activation of Matrix Metalloproteinase 9 in Myocardial Ischemia/Reperfusion
- PI3K/Akt: getting it right matters
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- Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease.
- PI3K and negative regulation of TLR signaling.
- Hyaluronan as an Immune Regulator in Human Diseases
Cited by
- Identification of the key differentially expressed genes and pathways involved in neutrophilia
- Antagonistic effect of selenium on lead-induced neutrophil apoptosis in chickens via miR-16-5p targeting of PiK3R1 and IGF1R.
- A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells
- Effects of Endotoxin Tolerance Induced by Porphyromonas gingivalis Lipopolysaccharide on Inflammatory Responses in Neutrophils
- Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach
- Gender Differences in Low-Molecular-Mass-Induced Acute Lung Inflammation in Mice
- Sialic acid-binding immunoglobulin-like lectin 9 as a potential therapeutic target for chronic obstructive pulmonary disease
- Comprehensive Analysis of Common Different Gene Expression Signatures in the Neutrophils of Sepsis
- Lung Hyaluronasome: Involvement of Low Molecular Weight Ha (Lmw-Ha) in Innate Immunity
- Network Pharmacology and Experimental Validation to Explore the Mechanism of Qing-Jin-Hua-Tan-Decoction Against Acute Lung Injury
- Exploration of the Pharmacological Mechanism of Bufei Nashen Pill in Treating Chronic Obstructive Pulmonary Disease Using Network Pharmacology Integrated Molecular Docking
- Mechanism and Experimental Verification of the Use of Rhodiola crenulata to Cytokine Storm Based on Network Pharmacology and Molecular Docking
- Hyaluronan promotes intracellular ROS production and apoptosis in TNFα-stimulated neutrophils
- Discovery of potential quality markers of Fritillariae thunbergii bulbus in pneumonia by combining UPLC-QTOF-MS, network pharmacology, and molecular docking
- Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease.
- A strategy for deciphering the bioactive metabolites of Farfarae Flos by the inter-individual variability of the antitussive effect.
- Mechanism and Experimental Verification of Rhodiola rosea L. for the Treatment of Acute Lung Injury Through Network Pharmacology and Molecular Docking
- Hyaluronic acid impacts hematological endpoints and spleen histological features in African catfish (Clarias gariepinus)
- Network Pharmacology Followed by Experimental Validation to Explore the Mechanism of Stigmasterol in Sangbaipi Decoction Regulating PI3K/Akt Signaling to Alleviate Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Development of a dexamethasone-hyaluronic acid conjugate with selective targeting effect for acute lung injury therapy.
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