Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
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Summary
This review focuses on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems.
- Type
- review
- Published
- 2018-07-05
- Cited by
- 246
- References
- 179
- Access
- Open access
- OpenAlex
- https://openalex.org/W2823725159
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:49697724
Keywords
Sepsis, Reprogramming, Organism, Catabolism, Biology
References
- Effects of bezafibrate in patients with chronic hepatitis C virus infection: combination with interferon and ribavirin
- Admission hypoglycaemia is associated with adverse outcome in community-acquired pneumonia
- Cellular metabolism of myeloid cells in sepsis
- Reduced PPARα Expression is Associated with Decreased Survival and Increased Tissue Bacterial Load in Sepsis
- Hypoglycemia in sepsis: risk factors and clinical characteristics.
- Chapter X. Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: respiration, apoptosis, and human disease
- Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles.
- Lactate Boosts TLR4 Signaling and NF-κB Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Transporters and MD-2 Up-Regulation
- The matabolic fuel regulatory system: implications for protein-sparing therapies during caloric deprivation and disease.
- Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
- Cutting Edge: Essential Role of Hypoxia Inducible Factor-1α in Development of Lipopolysaccharide-Induced Sepsis1
- Lactic Acidosis in Sepsis: It's Not All Anaerobic: Implications for Diagnosis and Management.
- Metabolic Reprogramming is Required for Antibody Production That is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B cells
- PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis
- MYOCARDIAL STRUCTURAL CHANGES IN LONG-TERM HUMAN SEVERE SEPSIS/SEPTIC SHOCK MAY BE RESPONSIBLE FOR CARDIAC DYSFUNCTION
- Initiation and execution of lipotoxic ER stress in pancreatic β-cells
- Fatty acids as modulators of the cellular production of reactive oxygen species.
- Hypoxia inducible factor‐1α induction by tumour necrosis factor‐α, but not by toll‐like receptor agonists, modulates cellular respiration in cultured human hepatocytes
- Histone Deacetylase Inhibitors Attenuate Acute Lung Injury During Cecal Ligation and Puncture-Induced Polymicrobial Sepsis
- Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes
Cited by
- Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels
- Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia
- Immunometabolism and Sepsis: A Role for HIF?
- iNOS as a metabolic enzyme under stress conditions.
- Analysis of Hematopoietic Stem Progenitor Cell Metabolism
- Sepsis Immunometabolism: From Defining Sepsis to Understanding How Energy Production Affects Immune Response
- The Impact of Diet and Health on Bone Stable Isotope Ratios: A Comparative Study
- 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
- Host-dependent induction of disease tolerance to infection by tetracycline antibiotics
- Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF.
- Identification of Biomarkers of Sepsis-Associated Acute Kidney Injury in Pediatric Patients Based on UPLC-QTOF/MS
- Metabolic regulation of neurodifferentiation in the adult brain
- Metabolic adaptations to infections at the organismal level
- Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis
- Hypoxia‐inducible factors in metabolic reprogramming during sepsis
- GLYCOCALYX IN ENDOTOXEMIA AND SEPSIS.
- Extensive Changes in Transcriptomic “Fingerprints” and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis
- l-theanine alleviates liver and kidney dysfunction in septic rats induced by cecal ligation and puncture.
- PKCdelta causes sepsis-induced cardiomyopathy by inducing mitochondrial dysfunction.
- Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
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