Icariin Activates Autophagy via Down-Regulation of the NF-κB Signaling-Mediated Apoptosis in Chondrocytes
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Summary
Results indicated that icariin protected against OA by suppressing inflammatory cytokines and apoptosis, through activation of autophagy via NF-κB inhibition, making it a promising compound for cartilage tissue engineering in the treatment of OA.
- Type
- article
- Published
- 2018-06-06
- Cited by
- 84
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W2806933589
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46937404
Keywords
Icariin, Autophagy, Chemistry, Apoptosis, Cell biology
References
- Low-dose γ-radiation inhibits IL-1β-induced dedifferentiation and inflammation of articular chondrocytes via blockage of catenin signaling
- Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis
- The role of mitochondria in osteoarthritis
- Metabolic Control of Autophagy
- Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways.
- Inflammation in osteoarthritis
- Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model.
- Millimeter Wave Treatment Inhibits Apoptosis of Chondrocytes via Regulation Dynamic Equilibrium of Intracellular Free Ca2+
- Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy.
- Autophagy Inhibition by Sustained Over-production of IL-6 Contributes to Arsenic Carcinogenesis
- Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3K/Akt Pathway in PC-12 Cells
- Blended Nanoparticle System Based on Miscible Structurally Similar Polymers: A Safe, Simple, Targeted, and Surprisingly High Efficiency Vehicle for Cancer Therapy
- Emerging regulators of the inflammatory process in osteoarthritis
- Protective effects of icariin on human umbilical vein endothelial cell injury induced by H2O2 in vitro.
- Icariin: a potential promoting compound for cartilage tissue engineering.
- ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis
- PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
- Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway
- Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNFα single-chain Fv antibody (ESBA105) designed for local therapeutic use
- Icariin Promotes Angiogenic Differentiation and Prevents Oxidative Stress‐Induced Autophagy in Endothelial Progenitor Cells
Cited by
- Shared KEGG pathways of icariin‐targeted genes and osteoarthritis
- Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells
- Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling
- Dopamine-melanin nanoparticles scavenge reactive oxygen and nitrogen species and activate autophagy for osteoarthritis therapy
- Conditioned medium of mesenchymal stem cells delays osteoarthritis progression in a rat model by protecting subchondral bone, maintaining matrix homeostasis, and enhancing autophagy
- Salidroside Suppresses IL-1β-Induced Apoptosis in Chondrocytes via Phosphatidylinositol 3-Kinases (PI3K)/Akt Signaling Inhibition
- Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis
- [Research progress in treatment of knee osteoarthritis by paracrine effect of stem cells].
- Icariin enhances intestinal barrier function by inhibiting NF-κB signaling pathways and modulating gut microbiota in a piglet model
- FSTL1 promotes nitric oxide-induced chondrocyte apoptosis via activating the SAPK/JNK/ caspase3 signaling pathway.
- Berberine mitigates high glucose-induced podocyte apoptosis by modulating autophagy via the mTOR/P70S6K/4EBP1 pathway.
- Ligustrazine ameliorates lipopolysaccharide-induced neurocognitive impairment by activating autophagy via the PI3K/AKT/mTOR pathway
- Exosomes derived from miRNA-210 overexpressing bone marrow mesenchymal stem cells protect lipopolysaccharide induced chondrocytes injury via the NF-κB pathway.
- [Effects of icariin on autophagy and exosome production of bone microvascular endothelial cells].
- CO-Releasing Molecule (CORM)-3 Ameliorates Spinal Cord-Blood Barrier Disruption Following Injury to the Spinal Cord
- Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies
- The Role of Autophagy and Mitophagy in Bone Metabolic Disorders
- Small molecule compounds promote the proliferation of chondrocytes and chondrogenic differentiation of stem cells in cartilage tissue engineering.
- Application of Some Herbal Medicine Used for the Treatment of Osteoarthritis and Chondrogenesis
- Identification of Diagnostic Biomarkers of Osteoarthritis Based on Multi-Chip Integrated Analysis and Machine Learning
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