Umbilical Cord Mesenchymal Stem Cells Conditioned Medium Promotes Aβ25-35 phagocytosis by Modulating Autophagy and Aβ-Degrading Enzymes in BV2 Cells
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Summary
It is suggested that ucMSCs-CM protect microglial and neuronal cells from Aβ25–35-induced cell death and promote Aβ phagocytosis by modulating autophagy and enhancing the expression of Aβ-degrading enzymes in microglia.
- Type
- article
- Published
- 2018-05-29
- Cited by
- 18
- References
- 63
- OpenAlex
- https://openalex.org/W2806751952
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44090810
Keywords
Phagocytosis, Mesenchymal stem cell, Autophagy, Umbilical cord, Cell biology
References
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Cited by
- Attenuating Spinal Cord Injury by Conditioned Medium from Bone Marrow Mesenchymal Stem Cells
- The beneficial roles of exercise training via autophagy in neurological diseases and possible mechanisms.
- Exploring the bi‐directional relationship between autophagy and Alzheimer’s disease
- Resveratrol Preincubation Enhances the Therapeutic Efficacy of hUC-MSCs by Improving Cell Migration and Modulating Neuroinflammation Mediated by MAPK Signaling in a Mouse Model of Alzheimer’s Disease
- Graphene oxide enhances β-amyloid clearance by inducing autophagy of microglia and neurons.
- The cytotoxicity of advanced glycation end products was attenuated by UCMSCs in human vaginal wall fibroblasts by inhibition of an inflammatory response and activation of PI3K/AKT/PTEN.
- Umbilical cord-derived mesenchymal stem cells in neurodegenerative disorders: from literature to clinical practice.
- Mesenchymal Stem Cell-Conditioned Medium Improves Mitochondrial Dysfunction and Suppresses Apoptosis in Okadaic Acid-Treated SH-SY5Y Cells by Extracellular Vesicle Mitochondrial Transfer
- The Role of Chronic Inflammatory Bone and Joint Disorders in the Pathogenesis and Progression of Alzheimer's Disease
- Noni Inhibits Neuronal Damage Caused by the Immune Reaction of Microglial Cells Activated by Doxorubicin
- Neurodevelopmental Clues to Neurodegeneration
- Common Factors of Alzheimer’s Disease and Rheumatoid Arthritis—Pathomechanism and Treatment
- The Emerging Role of the Interaction of Extracellular Vesicle and Autophagy—Novel Insights into Neurological Disorders
- Stem Cell Therapy for Alzheimer’s Disease: A Scoping Review for 2017–2022
- Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway.
- Perinatal Tissue-Derived Stem Cells: An Emerging Therapeutic Strategy for Challenging Neurodegenerative Diseases
- Mesenchymal stem cell-mediated regulation of neuroinflammation and amyloid-β clearance: A promising therapeutic strategy for Alzheimer's disease
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