Structural discordance in HIV-1 Vpu from brain isolate alarms amyloid fibril forming behavior- a computational perspective.
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Summary
The structural features of brain derived HIV-1 Vpu were consistent with the in silico amyloid prediction results that depicts the conformational change in the region 8-28, and the α-helix/β-sheet discordance of the predicted region was reflected in the simulation study highlighting the possible structural transition associated with HIV- 1 Vpu protein of brain isolate.
- Type
- article
- Published
- 2018-08-01
- Cited by
- 5
- References
- 92
- OpenAlex
- https://openalex.org/W2802199485
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14062456
Keywords
Amyloid (mycology), Amyloid fibril, Neurodegeneration, Fibril, Neurotoxicity
References
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