Structural discordance in HIV-1 Vpu from brain isolate alarms amyloid fibril forming behavior- a computational perspective.

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Summary

The structural features of brain derived HIV-1 Vpu were consistent with the in silico amyloid prediction results that depicts the conformational change in the region 8-28, and the α-helix/β-sheet discordance of the predicted region was reflected in the simulation study highlighting the possible structural transition associated with HIV- 1 Vpu protein of brain isolate.

Type
article
Published
2018-08-01
Cited by
5
References
92

Keywords

Amyloid (mycology), Amyloid fibril, Neurodegeneration, Fibril, Neurotoxicity

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