Spatial gene-by-environment mapping for schizophrenia reveals locale of upbringing effects beyond urban-rural differences
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Summary
This study provides insight into the degree of geospatial clustering of schizophrenia risk, and a novel analytic procedure provides a framework for decomposing variation in geosp spatial risk into G, E, and GxE components.
- Type
- preprint
- Published
- 2018-05-11
- Cited by
- 1
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2801432879
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:90118814
Keywords
Locale (computer software), Schizophrenia (object-oriented programming), Geospatial analysis, Confounding, Geography
References
- High loading of polygenic risk in cases with chronic schizophrenia
- FlashPCA2: principal component analysis of biobank-scale genotype datasets
- Mental Disorders in Urban Areas: An Ecological Study of Schizophrenia and Other Psychoses
- spatstat: An R Package for Analyzing Spatial Point Patterns
- Analysis of case-cohort designs.
- Gene-by-environment interaction studies have not properly controlled for potential confounders: The problem and the (simple) solution
- A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
- On the Voronoi estimator for the intensity of an inhomogeneous planar Poisson process
- Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies
- Modeling Spatial Variation in Disease Risk
- Family history, place and season of birth as risk factors for schizophrenia in Denmark: A replication and reanalysis
- An integrated map of genetic variation from 1,092 human genomes
- Biological Insights From 108 Schizophrenia-Associated Genetic Loci
- R2WinBUGS: A Package for Running WinBUGS from R
- Schizophrenia and urbanicity: a major environmental influence--conditional on genetic risk.
- Urbanization and traffic related exposures as risk factors for Schizophrenia
- Socioeconomic status at birth is associated with risk of schizophrenia: population-based multilevel study.
- Persons with schizophrenia migrate towards urban areas due to the development of their disorder or its prodromata.
- Do urbanicity and familial liability coparticipate in causing psychosis?
- No evidence of time trends in the urban–rural differences in schizophrenia risk among five million people born in Denmark from 1910 to 1986
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