Crystal Structures, Cytotoxicity, Cell Apoptosis Mechanism, and DNA Binding of Two 8-Hydroxylquinoline Zinc(II) Complexes
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Summary
Investigations on the binding properties of complexes I and II to ct-DNA by UV-Vis, circular dichroism spectra and agarose gel electrophoresis indicated that the two complexes could bind with cT-DNA via an intercalative mode.
- Type
- article
- Published
- 2018-04-23
- Cited by
- 2
- References
- 51
- OpenAlex
- https://openalex.org/W2801295232
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:103764523
Keywords
Chemistry, Cytotoxicity, Apoptosis, Agarose gel electrophoresis, Zinc
References
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- NS398 induces apoptosis in non-small cell lung cancer cells
- Synthesis of 8-hydroxyquinoline derivatives as novel antitumor agents.
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- Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction.
- Synthesis and antiproliferative activity of 8-hydroxyquinoline derivatives containing a 1,2,3-triazole moiety.
- Activities of a novel Schiff base copper(II) complex on growth inhibition and apoptosis induction toward MCF-7 human breast cancer cells via mitochondrial pathway.
- Platinum Compounds: a New Class of Potent Antitumour Agents
- Copper(I) and nickel(II) complexes with 1:1 vs. 1:2 coordination of ferrocenyl hydrazone ligands: do the geometry and composition of complexes affect DNA binding/cleavage, protein binding, antioxidant and cytotoxic activities?
- Arsenic induced neuronal apoptosis in guinea pigs is Ca2+ dependent and abrogated by chelation therapy: role of voltage gated calcium channels.
- Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine.
- Nimesulide aggravates redox imbalance and calcium dependent mitochondrial permeability transition leading to dysfunction in vitro.
- Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus.
- Mitochondrial intermembrane junctional complexes and their involvement in cell death.
- Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.
- The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes: control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway.
Cited by
- Preparation, Two-Photon Absorption, and Bioimaging Application of a Curcumin-Based Copper(II) Complex
- Zinc coordination complexes as anticancer agents
- Synthesis, structural characterization, and theoretical analysis of novel zinc(ii) schiff base complexes with halogen and hydrogen bonding interactions
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