MAIT cells contribute to protection against lethal influenza infection in vivo
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Summary
It is shown that in a murine model MAIT cells contribute to the protective host immune response to influenza virus infection, and constitute a potential target for therapeutic manipulation.
- Type
- preprint
- Published
- 2018-03-23
- Cited by
- 176
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W2790286952
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:53243068
Keywords
Adoptive cell transfer, Immunology, Biology, Cytokine storm, In vivo
References
- Mucosal-Associated Invariant T Cells Are More Activated in Chronic Hepatitis B, but Not Depleted in Blood: Reversal by Antiviral Therapy
- MR1-Restricted Vα19i Mucosal-Associated Invariant T Cells Are Innate T Cells in the Gut Lamina Propria That Provide a Rapid and Diverse Cytokine Response1
- CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL-12 + IL-18 in a TCR-independent manner
- Protective Role of Gamma Interferon during the Recall Response to Influenza Virus
- Functional heterogeneity and anti-mycobacterial effects of mouse mucosal associated invariant T (MAIT) cells specific for riboflavin metabolites
- Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection
- An Invariant T Cell Receptor α Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib–restricted α/β T Cell Subpopulation in Mammals
- Responses of Mouse Airway Epithelial Cells and Alveolar Macrophages to Virulent and Avirulent Strains of Influenza A Virus
- Stepwise Development of MAIT Cells in Mouse and Human
- MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection
- Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
- IL‐12 enhances IL‐2 function by inducing CD25 expression through a p38 mitogen‐activated protein kinase pathway
- Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain
- Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.
- Mucosal-associated invariant T cells: unconventional development and function.
- Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
- Circulating mucosal-associated invariant T cell levels and their cytokine levels in healthy adults.
- Case–Control Study of Risk Factors for Hospitalization Caused by Pandemic (H1N1) 2009
- The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage
- Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo
Cited by
- MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto
- Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells
- Role of Innate-like Lymphocytes in the Pathogenesis of Community Acquired Pneumonia
- Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals diverse functionality
- Mechanisms of Bacterial Superinfection Post-influenza: A Role for Unconventional T Cells
- Tissue-Resident Innate and Innate-Like Lymphocyte Responses to Viral Infection
- Transcriptional analysis defines TCR and cytokine-stimulated MAIT cells as rapid polyfunctional effector T cells that can coordinate the immune response
- Invariant T cell subsets in immune defense of oral mucosa and skin
- Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies
- Activation of MAIT cells plays a critical role in viral vector vaccine immunogenicity
- Inflammation drives an altered phenotype of mucosal-associated invariant T cells in chronic hepatitis D virus infection
- MAIT cells as attractive vaccine targets
- Type I interferons are important co-stimulatory signals during T cell receptor mediated MAIT cell activation
- Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses
- Mucosal-associated invariant T cells and disease
- The biology and functional importance of MAIT cells
- Capturing the antigen landscape: HLA-E, CD1 and MR1.
- TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions
- Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality
- TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses.
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