Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications
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Summary
From analysis, it is determined that dexamethasone‐phosphate, a pro‐drug widely‐used clinically, has molecular and pharmacokinetic properties that make it ill‐suited for use as a local therapy for hearing disorders.
- Type
- review
- Published
- 2018-03-11
- Cited by
- 161
- References
- 82
- Access
- Open access
- OpenAlex
- https://openalex.org/W2789474493
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4919280
Keywords
Perilymph, Round window, Pharmacokinetics, Inner ear, Cochlea
References
- Dexamethasone inner ear perfusion for the treatment of Meniere's disease: a prospective, randomized, double-blind, crossover trial.
- Intratympanic gentamicin instillation as treatment of unilateral Menière's disease: update of an ongoing study.
- Intrathecal 2-Hydroxypropyl-Beta-Cyclodextrin in a Single Patient with Niemann-Pick C1
- In vitro and in vivo pharmacokinetic study of a dexamethasone-releasing silicone for cochlear implants
- Chronic Neurotrophin Delivery Promotes Ectopic Neurite Growth From the Spiral Ganglion of Deafened Cochleae Without Compromising the Spatial Selectivity of Cochlear Implants
- Inner Ear Drug Delivery for Auditory Applications
- Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs
- Dexamethasone levels and base to apex concentration gradients in scala tympani perilymph following intracochlear delivery in the guinea pig
- Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs
- RAPID CLEARANCE OF METHYLPREDNISOLONE AFTER INTRATYMPANIC APPLICATION IN HUMANS: IN REPLY
- The role of intracochlear drug delivery devices in the management of inner ear disease
- Changes of Postoperative Impedances in Cochlear Implant Patients: The Short-Term Effects of Modified Electrode Surfaces and Intracochlear Corticosteroids
- Human Transporter Database: Comprehensive Knowledge and Discovery Tools in the Human Transporter Genes
- Localized cell and drug delivery for auditory prostheses.
- Principles of Local Drug Delivery to the Inner Ear
- Clinical Aspects of Round Window Membrane Permeability Under Normal and Pathological Conditions
- Tympanotomy with sealing of the round window as surgical salvage option in sudden idiopathic sensorineural hearing loss
- Entry of substances into perilymph through the bone of the otic capsule following intratympanic applicatons in guinea pigs: Implications for local drug delivery in humans
- Dual Origin of the Epithelium of the Mammalian Middle Ear
- Prediction of drug absorption using multivariate statistics.
Cited by
- Otic drug delivery systems: formulation principles and recent developments
- Inner ear drug delivery: Recent advances, challenges, and perspective
- A comparison of systemic and local dexamethasone administration: From perilymph/cochlea concentration to cochlear distribution
- Antisense Oligonucleotides for the Treatment of Inner Ear Dysfunction
- Pharmacological intervention in the field of ototoxicity
- Drug Diffusion Along an Intact Mammalian Cochlea
- Improving Clinical Outcomes in Cochlear Implantation Using Glucocorticoid Therapy: A Review.
- Intracochlear PLGA based implants for dexamethasone release: Challenges and solutions
- Stem Cell Based Drug Delivery for Protection of Auditory Neurons in a Guinea Pig Model of Cochlear Implantation
- Cochlear Pharmacokinetics - Micro-Computed Tomography and Learning-Prediction Modeling for Transport Parameter Determination
- Nanoparticle-based drug delivery in the inner ear: current challenges, limitations and opportunities
- Local Drug Delivery for the Treatment of Neurotology Disorders
- Advances and Challenges in Pharmaceutical Therapies to Prevent and Repair Cochlear Injuries From Noise
- Intratympanic Triamcinolone Acetonide as Treatment Option for Idiopathic Sudden Sensorineural Hearing Loss.
- Early phase trials of novel hearing therapeutics: Avenues and opportunities.
- Avenanthramide-C prevents noise- and drug-induced hearing loss while protecting auditory hair cells from oxidative stress
- Local Drug Delivery for Prevention of Hearing Loss
- Local Delivery of Therapeutics to the Inner Ear: The State of the Science
- Sustained-Release Triamcinolone Acetonide Hydrogels Reduce Hearing Threshold Shifts in a Model for Cochlear Implantation with Hearing Preservation
- Long-term effects and potential limits of intratympanic dexamethasone-loaded hydrogels combined with dexamethasone-eluting cochlear electrodes in a low-insertion trauma Guinea pig model.
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