Effectiveness of the sesquiterpene (-)-α-bisabolol in dogs with naturally acquired canine leishmaniosis: an exploratory clinical trial
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Summary
The natural compound seemed to induce a Th1 immune response that led to parasitological and clinical improvement without showing any safety issue, suggesting a high potential for the treatment of canine and human visceral leishmaniosis.
- Type
- article
- Published
- 2018-02-16
- Cited by
- 19
- References
- 36
- OpenAlex
- https://openalex.org/W2789273423
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3332486
Keywords
Meglumine antimoniate, Leishmania infantum, Medicine, Pharmacology, Whole blood
References
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- (-)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis.
- Long-term follow-up of dogs with leishmaniosis treated with meglumine antimoniate plus allopurinol versus miltefosine plus allopurinol
- Comparative study on the short term efficacy and adverse effects of miltefosine and meglumine antimoniate in dogs with natural leishmaniosis
- Experimental model for reproduction of canine visceral leishmaniosis by Leishmania infantum.
- Single-dose indigenous liposomal amphotericin B in the treatment of Indian visceral leishmaniasis: a phase 2 study.
- Association of water extract of green propolis and liposomal meglumine antimoniate in the treatment of experimental visceral leishmaniasis
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- Cytokine profiles in canine visceral leishmaniasis.
- Therapeutic Options for Visceral Leishmaniasis
- Epidemiological implications of the use of various methods for the diagnosis of canine leishmaniasis in dogs with different characteristics and in differing prevalence scenarios
- The antimicrobial activity of alpha-bisabolol and tea tree oil against Solobacterium moorei, a Gram-positive bacterium associated with halitosis.
- Immunoglobulin G and E responses in various stages of canine leishmaniosis.
- In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
- Canine leishmaniasis: bridging science, public health and politics.
- Canine leishmaniasis: epidemiological risk and the experimental model.
- Interferon-gamma (INF-gamma), IL4 expression levels and Leishmania DNA load as prognostic markers for monitoring response to treatment of leishmaniotic dogs with miltefosine and allopurinol.
Cited by
- Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease
- Clinical and Immunological Response in Dogs Naturally Infected by L. infantum Treated with a Nutritional Supplement
- Effect of α-Bisabolol and Its β-Cyclodextrin Complex as TetK and NorA Efflux Pump Inhibitors in Staphylococcus aureus Strains
- Evaluation of canine leishmaniosis vaccine CaniLeish® under field conditions in native dog populations from an endemic Mediterranean area - a randomized controlled trial.
- A Nutritional Supplement (DìLshTM) Improves the Inflammatory Cytokines Response, Oxidative Stress Markers and Clinical Signs in Dogs Naturally Infected by Leishmania infantum
- Pharmaceutical agents for treatment of leishmaniasis: a patent landscape
- Use of Natural Products in Leishmaniasis Chemotherapy: An Overview
- Eremanthus arboreus (Gardner) MacLeish (Candeeiro): natural source of α-Bisabolol
- Phytotherapie bei der Leishmaniose des Hundes
- Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Canine Leishmaniasis: Update on Epidemiology, Diagnosis, Treatment, and Prevention
- Effectiveness of an O-Alkyl Hydroxamate in Dogs with Naturally Acquired Canine Leishmaniosis: An Exploratory Clinical Trial
- Ein Update zur Leishmaniose des Hundes: Diagnostik, Therapie und Monitoring
- Exploring the leishmanicidal potential of terpenoids: a comprehensive review on mechanisms of cell death
- Microemulsions strongly promoted the activity of α-bisabolol against different Leishmania species and its skin permeation.
- World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis
- Agreement Document for the Study of Leishmaniasis from a One Health Approach in Spain
- Therapeutic vaccination reverses severe canine leishmaniasis: a case report
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