Cell Therapy in Organ Transplantation: Our Experience on the Clinical Translation of Regulatory T Cells
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Summary
This review will provide a brief introduction to human Tregs, their phenotypic and functional characterization and focuses on the experience to date at the clinical translation of Treg immunotherapy in the setting of solid organ transplantation.
- Type
- review
- Published
- 2018-02-26
- Cited by
- 66
- References
- 70
- Access
- Open access
- OpenAlex
- https://openalex.org/W2789270618
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3506755
Keywords
Immunosuppression, Transplantation, Medicine, Context (archaeology), Organ transplantation
References
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- Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous.
- IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo1
- Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation
- CD161 expression characterizes a sub-population of human regulatory T cells that produces IL-17 in a STAT3 dependent manner
- Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin1
- CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+ T cells contributes to their regulatory function
- Indefinite mouse heart allograft survival in recipient treated with CD4(+)CD25(+) regulatory T cells with indirect allospecificity and short term immunosuppression.
- Ido expression by dendritic cells: tolerance and tryptophan catabolism
- Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells
- DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells
- A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells
- Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation.
- Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell.
- CD161 is a marker of all human IL‐17‐producing T‐cell subsets and is induced by RORC
- DNA methylation controls Foxp3 gene expression
- Cancers complicating organ transplantation.
- Hot‐topic debate on tolerance: Immunosuppression withdrawal
- Clinical operational tolerance in liver transplantation: state-of-the-art perspective and future prospects.
Cited by
- Taking regulatory T-cell therapy one step further
- Integrated Proteome and Cytokine Profiles Reveal Ceruloplasmin Eliciting Liver Allograft Tolerance via Antioxidant Cascades
- Functional Role of Circular RNA in Regenerative Medicine.
- Adoptive Regulatory T Cell Therapy in a Patient with Systemic Lupus Erythematosus
- On the elusive TCR specificity of thymic regulatory T cells
- CAR‐T cells beyond CD19, UnCAR‐Ted territory
- IL‐2 therapy preferentially expands adoptively transferred donor‐specific Tregs improving skin allograft survival
- Transiently Activated Human Regulatory T Cells Upregulate BCL-XL Expression and Acquire a Functional Advantage in vivo
- Regulatory T cells as therapeutic targets and mediators
- Experimental and Modeling Framework for the Production of Cell and Protein-Based Biopharmaceutical Products
- Lymphangiogenesis in a mouse model of renal transplant rejection extends life span of the recipients.
- Next-generation regulatory T cell therapy
- Regulatory T cells in allogeneic hematopoietic stem cell transplantation: From the lab to the clinic.
- A modified flow cytometry method for objective estimation of human CD4+ regulatory T cells (CD4+ Tregs) in peripheral blood, via CD4/CD25/CD45RO/FoxP3 labeling
- Expansion processes for cell-based therapies.
- Identification of the immunological profile in rejection-free heart transplantation.
- The ONE Study: Evaluation of Regulatory Cell Therapy in Kidney Transplantation Using a Harmonized Trial Design
- Normothermic Machine Perfusion (NMP) of the Liver as a Platform for Therapeutic Interventions during Ex-Vivo Liver Preservation: A Review
- Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials
- Limited efficacy of rapamycin monotherapy in vascularized composite allotransplantation.
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