The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group
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Summary
This review paper summarizes the opinions and findings of a multidisciplinary team of experts, focusing on two main aspects of the issue: ENM interactions within the GIT and their possible consequences, and relevance of gastro-intestinal effects of inhaled ENM.
- Type
- review
- Published
- 2017-11-25
- Cited by
- 73
- References
- 143
- Access
- Open access
- OpenAlex
- https://openalex.org/W2770155693
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22022270
Keywords
Relevance (law), Mucus, Biology, Ecology
References
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- Nanoparticle-protein corona complexes govern the biological fates and functions of nanoparticles.
- Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells.
- Comparative Uptake Studies of Bioadhesive and Non-Bioadhesive Nanoparticles in Human Intestinal Cell Lines and Rats: The Effect of Mucus on Particle Adsorption and Transport
- How meaningful are risk determinations in the absence of a complete dataset? Making the case for publishing standardized test guideline and ‘no effect’ studies for evaluating the safety of nanoparticulates versus spurious ‘high effect’ results from single investigative studies
- Proteomic responses of human intestinal Caco‐2 cells exposed to silver nanoparticles and ionic silver
- Mammalian gastrointestinal tract parameters modulating the integrity, surface properties, and absorption of food‐relevant nanomaterials
- Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy
- Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model
- Comparative genotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by fluorescent microscopy of cytochalasin B‐blocked micronucleus formation
- Repeated dose (28 day) administration of silver nanoparticles of varied size and coating does not significantly alter the indigenous murine gut microbiome
- In vitro cytotoxicity of silver nanoparticles and zinc oxide nanoparticles to human epithelial colorectal adenocarcinoma (Caco-2) cells.
- Investigation of genotoxic and cytotoxic effects of micro- and nanosized titanium dioxide in six organs of mice in vivo.
- Cytotoxicity of carboxylic acid functionalized single wall carbon nanotubes on the human intestinal cell line Caco-2.
- Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management.
- The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century.
Cited by
- Sub-chronic inhalation of lead oxide nanoparticles revealed their broad distribution and tissue-specific subcellular localization in target organs
- Critical review of the safety assessment of titanium dioxide additives in food
- Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs
- Analysis of soluble or titanium dioxide derived titanium levels in human whole blood: consensus from an inter-laboratory comparison.
- In vitro intestinal epithelium responses to titanium dioxide nanoparticles.
- Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment.
- Toxicological Evaluation of SiO2 Nanoparticles by Zebrafish Embryo Toxicity Test
- Prebiotic protects against anatase titanium dioxide nanoparticles-induced microbiota-mediated colonic barrier defects
- Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats
- A systematic study on EN-998-2 premixed mortars modified with graphene-based materials
- A Brief Review about the Role of Nanomaterials, Mineral-Organic Nanoparticles, and Extra-Bone Calcification in Promoting Carcinogenesis and Tumor Progression
- Titanium dioxide nanoparticles elicit lower direct inhibitory effect on human gut microbiota than silver nanoparticles.
- Caracterização da exposição profissional a nanopartículas em processos de soldadura
- Hazard identification of pyrogenic synthetic amorphous silica (NM-203) after sub-chronic oral exposure in rat: A multitarget approach.
- Variability in the Clearance of Lead Oxide Nanoparticles is Associated with Alteration of Specific Membrane Transporters.
- Preclinical Evaluation of Antimicrobial Nanodrugs
- Transformation of Nanomaterials and Its Implications in Gut Nanotoxicology.
- The impact of synthetic amorphous silica (E 551) on differentiated Caco-2 cells, a model for the human intestinal epithelium.
- Pyrogenic and Precipitated Amorphous Silica Nanoparticles Differentially Affect Cell Responses to LPS in Human Macrophages
- Interplay between engineered nanomaterials and microbiota
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