MicroRNA‑212 inhibits the proliferation and invasion of human renal cell carcinoma by targeting FOXA1.
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Summary
It is suggested that miR‑212 suppresses RCC proliferation and invasion by modulating FOXA1, suggesting that mi R‑212 may have potential as a therapeutic target in RCC.
- Type
- article
- Published
- 2017-11-03
- Cited by
- 10
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W2766114204
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38725399
Keywords
FOXA1, Oncogene, Cancer research, Downregulation and upregulation, microRNA
References
- MEIS1 inhibits clear cell renal cell carcinoma cells proliferation and in vitro invasion or migration
- MicroRNA‐212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2
- MicroRNA-212 suppresses tumor growth of human hepatocellular carcinoma by targeting FOXA1
- Forkhead box protein A1 is a prognostic predictor and promotes tumor growth of gastric cancer
- miR‐212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical cancer cells
- FOXA1: master of steroid receptor function in cancer
- miRNAs in human cancer
- Current perspectives on FOXA1 regulation of androgen receptor signaling and prostate cancer
- miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development
- Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD.
- Epigenetic Regulation of miR-212 Expression in Lung Cancer
- FOXA1: a transcription factor with parallel functions in development and cancer
- Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinoma.
- MiR-212 exerts suppressive effect on SKOV3 ovarian cancer cells through targeting HBEGF
- Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
- MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma
- miR-629 Targets TRIM33 to Promote TGFβ/Smad Signaling and Metastatic Phenotypes in ccRCC
- Mammalian microRNAs predominantly act to decrease target mRNA levels
- MiR-212-3p inhibits glioblastoma cell proliferation by targeting SGK3
- miR-212 promotes pancreatic cancer cell growth and invasion by targeting the hedgehog signaling pathway receptor patched-1
Cited by
- Long non-coding RNA, HOTAIRM1, promotes glioma malignancy by forming a ceRNA network
- Observations on Solitary Versus Multiple Isolated Pancreatic Metastases of Renal Cell Carcinoma: Another Indication of a Seed and Soil Mechanism?
- miR-212-3p reduced proliferation, and promoted apoptosis of fibroblast-like synoviocytes via down-regulating SOX5 in rheumatoid arthritis.
- Down‐regulated FOXA1 in early‐onset pre‐eclampsia induces apoptosis, and inhibits migration and invasion of trophoblast cells
- Expressions and related mechanisms of miR-212 and KLF4 in rats with acute kidney injury
- FAST1 Predicts Poor Survival of Renal Carcinoma and Promotes Its Progression Through the TGF-β/Smad Pathway
- Biology of cancer; from cellular and molecular mechanisms to developmental processes and adaptation.
- MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysis
- A comprehensive analysis of the FOX family for predicting kidney renal clear cell carcinoma prognosis and the oncogenic role of FOXG1
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